RRC ID 46525
著者 Vidal-Gadea A, Topper S, Young L, Crisp A, Kressin L, Elbel E, Maples T, Brauner M, Erbguth K, Axelrod A, Gottschalk A, Siegel D, Pierce-Shimomura JT.
タイトル Caenorhabditis elegans selects distinct crawling and swimming gaits via dopamine and serotonin.
ジャーナル Proc Natl Acad Sci U S A
Abstract Many animals, including humans, select alternate forms of motion (gaits) to move efficiently in different environments. However, it is unclear whether primitive animals, such as nematodes, also use this strategy. We used a multifaceted approach to study how the nematode Caenorhabditis elegans freely moves into and out of water. We demonstrate that C. elegans uses biogenic amines to switch between distinct crawling and swimming gaits. Dopamine is necessary and sufficient to initiate and maintain crawling after swimming. Serotonin is necessary and sufficient to transition from crawling to swimming and to inhibit a set of crawl-specific behaviors. Further study of locomotory switching in C. elegans and its dependence on biogenic amines may provide insight into how gait transitions are performed in other animals.
巻・号 108(42)
ページ 17504-9
公開日 2011-10-18
DOI 10.1073/pnas.1108673108
PII 1108673108
PMID 21969584
PMC PMC3198358
MeSH Animals Animals, Genetically Modified Behavior, Animal / physiology Biomechanical Phenomena Caenorhabditis elegans / physiology* Dopamine / physiology* Dopaminergic Neurons / physiology Gait / physiology Locomotion / physiology* Serotonergic Neurons / physiology Serotonin / physiology* Signal Transduction / physiology Swimming / physiology Video Recording Viscosity Water
IF 9.412
引用数 71
WOS 分野 NEUROSCIENCES
リソース情報
線虫 tm1062 tm1392 tm2654 tm2146 tm2104 tm1325