RRC ID 46342
著者 Gaertner BE, Parmenter MD, Rockman MV, Kruglyak L, Phillips PC.
タイトル More than the sum of its parts: a complex epistatic network underlies natural variation in thermal preference behavior in Caenorhabditis elegans.
ジャーナル Genetics
Abstract Behavior is a complex trait that results from interactions among multiple genes and the environment. Both additive and nonadditive effects are expected to contribute to broad-sense heritability of complex phenotypes, although the relative contribution of each of these mechanisms is unknown. Here, we mapped genetic variation in the correlated phenotypes of thermal preference and isothermal dispersion in the nematode Caenorhabditis elegans. Genetic variation underlying these traits is characterized by a set of linked quantitative trait loci (QTL) that interact in a complex epistatic network. In particular, two loci located on the X chromosome interact with one another to generate extreme thermophilic behavior and are responsible for ∼50% of the total variation observed in a cross between two parental lines, even though these loci individually explain very little of the among-line variation. Our results demonstrate that simultaneously considering the influence of a quantitative trait locus (QTL) on multiple scales of behavior can inform the physiological mechanism of the QTL and show that epistasis can explain significant proportions of otherwise unattributed variance within populations.
巻・号 192(4)
ページ 1533-42
公開日 2012-12-1
DOI 10.1534/genetics.112.142877
PII genetics.112.142877
PMID 23086219
PMC PMC3512158
MeSH Animals Behavior, Animal* Caenorhabditis elegans / genetics* Caenorhabditis elegans / physiology Caenorhabditis elegans Proteins / genetics Chromosome Mapping Epistasis, Genetic* Genetic Variation Phenotype Quantitative Trait Loci* Receptors, Neuropeptide Y / genetics X Chromosome
IF 4.015
引用数 40
WOS 分野 GENETICS & HEREDITY
リソース情報
線虫 tm1247 tm2166 tm239 tm474 tm733