論文 - 詳細
| RRC ID | 46337 |
|---|---|
| 著者 | Sato M, Sato K. |
| タイトル | Degradation of paternal mitochondria by fertilization-triggered autophagy in C. elegans embryos. |
| ジャーナル | Science |
| Abstract |
The mitochondrial genome is believed to be maternally inherited in many eukaryotes. Sperm-derived paternal mitochondria enter the oocyte cytoplasm upon fertilization and then normally disappear during early embryogenesis. However, the mechanism responsible for this clearance has been unknown. Here, we show that autophagy, which delivers cytosolic components to lysosomes for degradation, is required for the elimination of paternal mitochondria in Caenorhabditis elegans. Immediately after fertilization, sperm-derived components trigger the localized induction of autophagy around sperm mitochondria. Autophagosomes engulf paternal mitochondria, resulting in their lysosomal degradation during early embryogenesis. In autophagy-defective zygotes, paternal mitochondria and their genome remain even in the first larval stage. Thus, fertilization-triggered autophagy is required for selective degradation of paternal mitochondria and thereby maternal inheritance of mitochondrial DNA. |
| 巻・号 | 334(6059) |
| ページ | 1141-4 |
| 公開日 | 2011-11-25 |
| DOI | 10.1126/science.1210333 |
| PII | science.1210333 |
| PMID | 21998252 |
| MeSH | Animals Autophagy* Caenorhabditis elegans / embryology* Caenorhabditis elegans / genetics Caenorhabditis elegans / physiology Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism DNA, Helminth / analysis DNA, Helminth / genetics DNA, Mitochondrial / analysis DNA, Mitochondrial / genetics Embryo, Nonmammalian / physiology* Embryonic Development Fertilization* Genome, Mitochondrial Hermaphroditic Organisms Lysosomes / metabolism Male Mitochondria / genetics Mitochondria / metabolism* Mutation Oocytes / physiology Phagosomes / physiology* Recombinant Fusion Proteins / metabolism Spermatozoa / ultrastructure Ubiquitination |
| IF | 41.846 |
| 引用数 | 241 |
| WOS 分野 | CELL BIOLOGY |
| リソース情報 | |
| 線虫 | tm3489 |