| RRC ID |
46272
|
| 著者 |
Mills H, Wragg R, Hapiak V, Castelletto M, Zahratka J, Harris G, Summers P, Korchnak A, Law W, Bamber B, Komuniecki R.
|
| タイトル |
Monoamines and neuropeptides interact to inhibit aversive behaviour in Caenorhabditis elegans.
|
| ジャーナル |
EMBO J
|
| Abstract |
Pain modulation is complex, but noradrenergic signalling promotes anti-nociception, with α(2)-adrenergic agonists used clinically. To better understand the noradrenergic/peptidergic modulation of nociception, we examined the octopaminergic inhibition of aversive behaviour initiated by the Caenorhabditis elegans nociceptive ASH sensory neurons. Octopamine (OA), the invertebrate counterpart of norepinephrine, modulates sensory-mediated reversal through three α-adrenergic-like OA receptors. OCTR-1 and SER-3 antagonistically modulate ASH signalling directly, with OCTR-1 signalling mediated by Gα(o). In contrast, SER-6 inhibits aversive responses by stimulating the release of an array of 'inhibitory' neuropeptides that activate receptors on sensory neurons mediating attraction or repulsion, suggesting that peptidergic signalling may integrate multiple sensory inputs to modulate locomotory transitions. These studies highlight the complexity of octopaminergic/peptidergic interactions, the role of OA in activating global peptidergic signalling cascades and the similarities of this modulatory network to the noradrenergic inhibition of nociception in mammals, where norepinephrine suppresses chronic pain through inhibitory α(2)-adrenoreceptors on afferent nociceptors and stimulatory α(1)-receptors on inhibitory peptidergic interneurons.
|
| 巻・号 |
31(3)
|
| ページ |
667-78
|
| 公開日 |
2012-2-1
|
| DOI |
10.1038/emboj.2011.422
|
| PII |
emboj2011422
|
| PMID |
22124329
|
| PMC |
PMC3273394
|
| MeSH |
1-Octanol / pharmacology
Animals
Animals, Genetically Modified
Avoidance Learning*
Biogenic Monoamines / metabolism*
Caenorhabditis elegans / physiology*
GTP-Binding Proteins / metabolism
Neuropeptides / metabolism*
Polymerase Chain Reaction
Serotonin / pharmacology
Signal Transduction
Xenopus laevis
|
| IF |
9.889
|
| 引用数 |
41
|
|
WOS 分野
|
BIOCHEMISTRY & MOLECULAR BIOLOGY
CELL BIOLOGY
|
| リソース情報 |
| 線虫 |
tm2146
tm2243
tm2184
tm3572
tm2765
tm2974
tm3082
tm3210
tm238
tm2104 |
