論文 - 詳細
| RRC ID | 46243 |
|---|---|
| 著者 | Yee C, Florica R, Fillingham J, Killeen MT. |
| タイトル | ENU-3 functions in an UNC-6/netrin dependent pathway parallel to UNC-40/DCC/frazzled for outgrowth and guidance of the touch receptor neurons in C. elegans. |
| ジャーナル | Dev Dyn |
| Abstract |
BACKGROUND:UNC-6 and SLT-1 guide the migrations of the ventrally directed processes of the AVM and PVM touch receptor neurons and UNC-6 guides the axons of the DA and DB classes of motor neurons in C. elegans. The UNC-6 receptors are UNC-5 and UNC-40. The axon outgrowth defects of a subset of the DB motor neurons in the absence of UNC-5 are enhanced by mutations in enu-3. RESULTS:An enu-3 mutation enhances defects in ventral guidance of the processes of the AVM and PVM touch receptor neurons, the dorsal guidance of the distal tip cell and causes additional architectural defects in axons in unc-40 mutant strains in an UNC-6 dependent manner. These observations suggest that ENU-3 and UNC-40 function in parallel pathways dependent on UNC-6. ENU-3 depends on the presence of UNC-40 for its full effect on motor neuron axon outgrowth. CONCLUSIONS:ENU-3 works in an UNC-6 dependent pathway parallel to UNC-40 in ventral guidance of AVM and PVM and in dorsal guidance of the distal tip cells. Motor neuron axon outgrowth defects are caused by the presence of UNC-40 and the absence of functional UNC-5 or UNC-6 and defects are enhanced by the absence of functional ENU-3. |
| 巻・号 | 243(3) |
| ページ | 459-67 |
| 公開日 | 2014-3-1 |
| DOI | 10.1002/dvdy.24063 |
| PMID | 24123761 |
| MeSH | Animals Axons / metabolism* Caenorhabditis elegans / cytology Caenorhabditis elegans / embryology* Caenorhabditis elegans / genetics Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Cell Adhesion Molecules / genetics Cell Adhesion Molecules / metabolism* Membrane Proteins / genetics Membrane Proteins / metabolism* Motor Neurons / cytology Motor Neurons / metabolism* Mutation Nerve Tissue Proteins / genetics Nerve Tissue Proteins / metabolism* Netrins |
| IF | 3.275 |
| 引用数 | 2 |
| WOS 分野 | ANATOMY & MORPHOLOGY DEVELOPMENTAL BIOLOGY |
| リソース情報 | |
| 線虫 | tm4519 tm5504 |