RRC ID 46207
著者 Suo S, Ishiura S.
タイトル Dopamine modulates acetylcholine release via octopamine and CREB signaling in Caenorhabditis elegans.
ジャーナル PLoS One
Abstract Animals change their behavior and metabolism in response to external stimuli. cAMP response element binding protein (CREB) is a signal-activated transcription factor that enables the coupling of extracellular signals and gene expression to induce adaptive changes. Biogenic amine neurotransmitters regulate CREB and such regulation is important for long-term changes in various nervous system functions, including learning and drug addiction. In Caenorhabditis elegans, the amine neurotransmitter octopamine activates a CREB homolog, CRH-1, in cholinergic SIA neurons, whereas dopamine suppresses CREB activation by inhibiting octopamine signaling in response to food stimuli. However, the physiological role of this activation is unknown. In this study, the effect of dopamine, octopamine, and CREB on acetylcholine signaling was analyzed using the acetylcholinesterase inhibitor aldicarb. Mutants with decreased dopamine signaling exhibited reduced acetylcholine signaling, and octopamine and CREB functioned downstream of dopamine in this regulation. This study demonstrates that the regulation of CREB by amine neurotransmitters modulates acetylcholine release from the neurons of C. elegans.
巻・号 8(8)
ページ e72578
公開日 2013-1-1
DOI 10.1371/journal.pone.0072578
PII PONE-D-13-11181
PMID 23977320
PMC PMC3745381
MeSH Acetylcholine / metabolism* Aldicarb / pharmacology Animals Caenorhabditis elegans / drug effects Caenorhabditis elegans / genetics Caenorhabditis elegans Proteins / metabolism* Cholinergic Neurons / metabolism Cyclic AMP Response Element-Binding Protein / metabolism* Dopamine / metabolism* Genes, Helminth Levamisole / pharmacology Mutation / genetics Octopamine / metabolism* RNA Interference / drug effects Signal Transduction* / drug effects Suppression, Genetic / drug effects Transcription Factors / metabolism*
IF 2.74
引用数 10
WOS 分野 NEUROSCIENCES
リソース情報
線虫 tm2261