論文 - 詳細
| RRC ID | 46147 |
|---|---|
| 著者 | Labella S, Woglar A, Jantsch V, Zetka M. |
| タイトル | Polo kinases establish links between meiotic chromosomes and cytoskeletal forces essential for homolog pairing. |
| ジャーナル | Dev Cell |
| Abstract |
During meiosis, chromosomes must find and align with their homologous partners. SUN and KASH-domain protein pairs play a conserved role by establishing transient linkages between chromosome ends and cytoskeletal forces across the intact nuclear envelope (NE). In C. elegans, a pairing center (PC) on each chromosome mediates homolog pairing and linkage to the microtubule network. We report that the polo kinases PLK-1 and PLK-2 are targeted to the PC by ZIM/HIM-8-pairing proteins. Loss of plk-2 inhibits chromosome pairing and licenses synapsis between nonhomologous chromosomes, indicating that PLK-2 is required for PC-mediated interhomolog interactions. plk-2 is also required for meiosis-specific phosphorylation of SUN-1 and establishment of dynamic SUN/KASH (SUN-1/ZYG-12) modules that promote homolog pairing. Our results provide key insights into the regulation of homolog pairing and reveal that targeting of polo-like kinases to the NE by meiotic chromosomes establishes the conserved linkages to cytoskeletal forces needed for homology assessment. |
| 巻・号 | 21(5) |
| ページ | 948-58 |
| 公開日 | 2011-11-15 |
| DOI | 10.1016/j.devcel.2011.07.011 |
| PII | S1534-5807(11)00303-0 |
| PMID | 22018921 |
| MeSH | Animals Caenorhabditis elegans / genetics* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Cell Cycle Proteins / genetics Cell Cycle Proteins / metabolism* Chromosome Pairing / genetics* Cytoskeleton / genetics* Cytoskeleton / metabolism Meiosis / genetics* Nuclear Envelope / genetics Nuclear Envelope / metabolism Protein Serine-Threonine Kinases / genetics Protein Serine-Threonine Kinases / metabolism* Proto-Oncogene Proteins / genetics Proto-Oncogene Proteins / metabolism* |
| IF | 10.092 |
| 引用数 | 59 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY CELL BIOLOGY |
| リソース情報 | |
| 線虫 | tm3655 tm1395 |