RRC ID 45999
著者 Jones MR, Rose AM, Baillie DL.
タイトル The ortholog of the human proto-oncogene ROS1 is required for epithelial development in C. elegans.
ジャーナル Genesis
Abstract The orphan receptor ROS1 is a human proto-oncogene, mutations of which are found in an increasing number of cancers. Little is known about the role of ROS1, however in vertebrates it has been implicated in promoting differentiation programs in specialized epithelial tissues. In this study we show that the C. elegans ortholog of ROS1, the receptor tyrosine kinase ROL-3, has an essential role in orchestrating the morphogenesis and development of specialized epidermal tissues, highlighting a potentially conserved function in coordinating crosstalk between developing epithelial cells. We also provide evidence of a direct relationship between ROL-3, the mucin SRAP-1, and BCC-1, the homolog of mRNA regulating protein Bicaudal-C. This study answers a longstanding question as to the developmental function of ROL-3, identifies three new genes that are expressed and function in the developing epithelium of C. elegans, and introduces the nematode as a potentially powerful model system for investigating the increasingly important, yet poorly understood, human oncogene ROS1.
巻・号 51(8)
ページ 545-61
公開日 2013-8-1
DOI 10.1002/dvg.22405
PMID 23733356
PMC PMC4232869
MeSH Animals Caenorhabditis elegans / genetics* Caenorhabditis elegans / growth & development Caenorhabditis elegans / metabolism Caenorhabditis elegans Proteins / genetics* Caenorhabditis elegans Proteins / metabolism Epithelium / growth & development Epithelium / metabolism* Morphogenesis / genetics Mucins / metabolism Proto-Oncogene Mas Proto-Oncogene Proteins / genetics* Proto-Oncogene Proteins / metabolism Receptor Protein-Tyrosine Kinases / genetics* Receptor Protein-Tyrosine Kinases / metabolism
IF 1.76
引用数 1
WOS 分野 GENETICS & HEREDITY DEVELOPMENTAL BIOLOGY
リソース情報
線虫 tm3908 tm2831 tm3821 tm3921