論文 - 詳細
| RRC ID | 45925 |
|---|---|
| 著者 | Barros AG, Bridi JC, de Souza BR, de Castro Júnior C, de Lima Torres KC, Malard L, Jorio A, de Miranda DM, Ashrafi K, Romano-Silva MA. |
| タイトル | Dopamine signaling regulates fat content through β-oxidation in Caenorhabditis elegans. |
| ジャーナル | PLoS One |
| Abstract |
The regulation of energy balance involves an intricate interplay between neural mechanisms that respond to internal and external cues of energy demand and food availability. Compelling data have implicated the neurotransmitter dopamine as an important part of body weight regulation. However, the precise mechanisms through which dopamine regulates energy homeostasis remain poorly understood. Here, we investigate mechanisms through which dopamine modulates energy storage. We showed that dopamine signaling regulates fat reservoirs in Caenorhabditis elegans. We found that the fat reducing effects of dopamine were dependent on dopaminergic receptors and a set of fat oxidation enzymes. Our findings reveal an ancient role for dopaminergic regulation of fat and suggest that dopamine signaling elicits this outcome through cascades that ultimately mobilize peripheral fat depots. |
| 巻・号 | 9(1) |
| ページ | e85874 |
| 公開日 | 2014-1-1 |
| DOI | 10.1371/journal.pone.0085874 |
| PII | PONE-D-13-04162 |
| PMID | 24465759 |
| PMC | PMC3899111 |
| MeSH | Animals Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism Dopamine / metabolism* Dopamine / pharmacology Dopamine Agents / metabolism Dopamine Agents / pharmacology Energy Metabolism / drug effects Fats / metabolism* Gene Expression Homeostasis / drug effects Lipid Metabolism / drug effects Microscopy, Fluorescence Mutation Oxidation-Reduction / drug effects RNA Interference Receptors, Dopamine / genetics Receptors, Dopamine / metabolism Reverse Transcriptase Polymerase Chain Reaction Serotonin / pharmacology Serotonin Receptor Agonists / pharmacology Signal Transduction* Time Factors |
| IF | 2.74 |
| 引用数 | 8 |
| WOS 分野 | NEUROSCIENCES |
| リソース情報 | |
| 線虫 | tm351 tm1037 |