RRC ID 45905
著者 Zhu Z, Liu J, Yi P, Tian D, Chai Y, Li W, Ou G.
タイトル A proneural gene controls C. elegans neuroblast asymmetric division and migration.
ジャーナル FEBS Lett
Abstract Proneural genes control the generation of neuroblasts from the neuroepithelium, but their functions in neuroblast asymmetric division and migration remain elusive. Here, we identified Caenorhabditiselegans mutants of a proneural transcription factor (TF) lin-32, in which Q neuroblasts are produced. We showed that LIN-32 functions in parallel with a storkhead TF, HAM-1, to regulate Q neuroblast asymmetric division, and that Q neuroblast migration is inhibited in lin-32 alleles. Consistently, lin-32 is expressed throughout Q neuroblast lineage, suggesting that LIN-32 may promote different target gene expression. Our studies thus uncovered previously unknown functions of a proneural gene in neuroblast development.
巻・号 588(7)
ページ 1136-43
公開日 2014-4-2
DOI 10.1016/j.febslet.2014.02.036
PII S0014-5793(14)00156-2
PMID 24589937
MeSH Alleles Animals Asymmetric Cell Division* Caenorhabditis elegans / cytology Caenorhabditis elegans / genetics* Caenorhabditis elegans / metabolism Caenorhabditis elegans Proteins / genetics* Caenorhabditis elegans Proteins / metabolism Cell Movement* Cell Size Gene Expression Regulation, Developmental Microscopy, Fluorescence Neurons / physiology* Time-Lapse Imaging Transcription Factors / genetics* Transcription Factors / metabolism
IF 3.057
引用数 7
WOS 分野 BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY
リソース情報
線虫 tm1446 tm1768