RRC ID 45746
著者 Hisamoto N, Li C, Yoshida M, Matsumoto K.
タイトル The C. elegans HGF/plasminogen-like protein SVH-1 has protease-dependent and -independent functions.
ジャーナル Cell Rep
Abstract Hepatocyte growth factor (HGF) and fibrinolytic serine protease plasminogen may have evolved from a common ancestor in vertebrates. This has been hard to ascertain, as no ancestral form has been identified in other lineages. In Caenorhabditis elegans, an HGF/plasminogen-like protein SVH-1 regulates axon regeneration via the HGF receptor homolog SVH-2. In this study, we report that both the svh-1 and svh-2 genes are conserved in many invertebrates. We also show that SVH-1 has an additional function, independent of SVH-2, which controls larval growth. SVH-1 protease activity is essential for larval growth, but not for axon regeneration. Deletion of svh-1 causes abnormal accumulation of FBL-1 protein, an extracellular matrix (ECM) component fibulin, around the pharynx, and this growth defect is partially suppressed by FBL-1 depletion. These results suggest that SVH-1 acts as both a growth factor and a protease, and they also provide insights into the evolution of HGF/plasminogen in animals.
巻・号 9(5)
ページ 1628-1634
公開日 2014-12-11
DOI 10.1016/j.celrep.2014.10.056
PII S2211-1247(14)00925-5
PMID 25464847
MeSH Animals Caenorhabditis elegans / enzymology* Caenorhabditis elegans / growth & development Caenorhabditis elegans Proteins / physiology* Calcium-Binding Proteins / metabolism Conserved Sequence Evolution, Molecular Gastrointestinal Motility Gene Expression Hepatocyte Growth Factor / genetics Intercellular Signaling Peptides and Proteins / physiology* Larva / enzymology Larva / growth & development Muscle Contraction Organ Specificity Pharynx / physiology Plasminogen / genetics
IF 8.109
引用数 4
WOS 分野 CELL BIOLOGY
リソース情報
線虫 tm2646 tm737