論文 - 詳細
| RRC ID | 45692 |
|---|---|
| 著者 | Bond MR, Ghosh SK, Wang P, Hanover JA. |
| タイトル | Conserved nutrient sensor O-GlcNAc transferase is integral to C. elegans pathogen-specific immunity. |
| ジャーナル | PLoS One |
| Abstract |
Discriminating pathogenic bacteria from bacteria used as a food source is key to Caenorhabidits elegans immunity. Using mutants defective in the enzymes of O-linked N-acetylglucosamine (O-GlcNAc) cycling, we examined the role of this nutrient-sensing pathway in the C. elegans innate immune response. Genetic analysis showed that deletion of O-GlcNAc transferase (ogt-1) yielded animals hypersensitive to the human pathogen S. aureus but not to P. aeruginosa. Genetic interaction studies revealed that nutrient-responsive OGT-1 acts through the conserved β-catenin (BAR-1) pathway and in concert with p38 MAPK (PMK-1) to modulate the immune response to S. aureus. Moreover, whole genome transcriptional profiling revealed that O-GlcNAc cycling mutants exhibited deregulation of unique stress- and immune-responsive genes. The participation of nutrient sensor OGT-1 in an immunity module evolutionarily conserved from C. elegans to humans reveals an unexplored nexus between nutrient availability and a pathogen-specific immune response. |
| 巻・号 | 9(12) |
| ページ | e113231 |
| 公開日 | 2014-1-1 |
| DOI | 10.1371/journal.pone.0113231 |
| PII | PONE-D-14-39845 |
| PMID | 25474640 |
| PMC | PMC4256294 |
| MeSH | Acetylglucosamine Animals Caenorhabditis elegans / genetics* Caenorhabditis elegans / immunology* Caenorhabditis elegans / microbiology Food Humans Immunity, Innate / genetics* N-Acetylglucosaminyltransferases / genetics* N-Acetylglucosaminyltransferases / metabolism Signal Transduction / genetics Staphylococcus aureus / immunology Staphylococcus aureus / pathogenicity beta Catenin / genetics beta Catenin / metabolism p38 Mitogen-Activated Protein Kinases / genetics p38 Mitogen-Activated Protein Kinases / metabolism |
| IF | 2.74 |
| 引用数 | 16 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY |
| リソース情報 | |
| 線虫 | tm3642 |