RRC ID 45691
著者 Bhattacharya R, Touroutine D, Barbagallo B, Climer J, Lambert CM, Clark CM, Alkema MJ, Francis MM.
タイトル A conserved dopamine-cholecystokinin signaling pathway shapes context-dependent Caenorhabditis elegans behavior.
ジャーナル PLoS Genet
Abstract An organism's ability to thrive in changing environmental conditions requires the capacity for making flexible behavioral responses. Here we show that, in the nematode Caenorhabditis elegans, foraging responses to changes in food availability require nlp-12, a homolog of the mammalian neuropeptide cholecystokinin (CCK). nlp-12 expression is limited to a single interneuron (DVA) that is postsynaptic to dopaminergic neurons involved in food-sensing, and presynaptic to locomotory control neurons. NLP-12 release from DVA is regulated through the D1-like dopamine receptor DOP-1, and both nlp-12 and dop-1 are required for normal local food searching responses. nlp-12/CCK overexpression recapitulates characteristics of local food searching, and DVA ablation or mutations disrupting muscle acetylcholine receptor function attenuate these effects. Conversely, nlp-12 deletion reverses behavioral and functional changes associated with genetically enhanced muscle acetylcholine receptor activity. Thus, our data suggest that dopamine-mediated sensory information about food availability shapes foraging in a context-dependent manner through peptide modulation of locomotory output.
巻・号 10(8)
ページ e1004584
公開日 2014-8-1
DOI 10.1371/journal.pgen.1004584
PII PGENETICS-D-14-00901
PMID 25167143
PMC PMC4148232
MeSH Animals Behavior, Animal* Caenorhabditis elegans Caenorhabditis elegans Proteins / genetics* Caenorhabditis elegans Proteins / metabolism Cholecystokinin / genetics Cholecystokinin / metabolism* Dopamine / genetics Dopamine / metabolism* Dopaminergic Neurons Mutation Receptors, Dopamine Receptors, Dopamine D1 / genetics* Receptors, Dopamine D1 / metabolism Signal Transduction / genetics Synaptic Transmission
IF 5.175
引用数 22
WOS 分野 GENETICS & HEREDITY
リソース情報
線虫 tm3082