論文 - 詳細
| RRC ID | 45682 |
|---|---|
| 著者 | Babu V, Hofmann K, Schumacher B. |
| タイトル | A C. elegans homolog of the Cockayne syndrome complementation group A gene. |
| ジャーナル | DNA Repair (Amst) |
| Abstract |
Cockayne syndrome (CS) is a debilitating and complex disorder that results from inherited mutations in the CS complementation genes A and B, CSA and CSB. The links between the molecular functions of the CS genes and the complex pathophysiology of CS are as of yet poorly understood and are the subject of intense debate. While mouse models reflect the complexity of CS, studies on simpler genetic models might shed new light on the consequences of CS mutations. Here we describe a functional homolog of the human CSA gene in Caenorhabditis elegans. Similar to its human counterpart, mutations in the nematode csa-1 gene lead to developmental growth defects as a consequence of DNA lesions. |
| 巻・号 | 24 |
| ページ | 57-62 |
| 公開日 | 2014-12-1 |
| DOI | 10.1016/j.dnarep.2014.09.011 |
| PII | S1568-7864(14)00242-0 |
| PMID | 25453470 |
| PMC | PMC4255241 |
| MeSH | Animals Caenorhabditis elegans / drug effects Caenorhabditis elegans / genetics* Caenorhabditis elegans / growth & development Caenorhabditis elegans / radiation effects Caenorhabditis elegans Proteins / genetics* Caenorhabditis elegans Proteins / metabolism DNA Damage / radiation effects DNA Repair / genetics DNA Repair / radiation effects DNA Repair Enzymes / genetics* DNA Repair Enzymes / metabolism Female Mutation Polycyclic Sesquiterpenes Sequence Homology, Amino Acid Sesquiterpenes Transcription Factors / genetics* Transcription Factors / metabolism Ultraviolet Rays |
| IF | 3.339 |
| 引用数 | 11 |
| WOS 分野 | TOXICOLOGY GENETICS & HEREDITY |
| リソース情報 | |
| 線虫 | tm3886 tm4539 tm5232 tm4916 |