RRC ID 45656
著者 Wei X, Howell AS, Dong X, Taylor CA, Cooper RC, Zhang J, Zou W, Sherwood DR, Shen K.
タイトル The unfolded protein response is required for dendrite morphogenesis.
ジャーナル Elife
Abstract Precise patterning of dendritic fields is essential for the formation and function of neuronal circuits. During development, dendrites acquire their morphology by exuberant branching. How neurons cope with the increased load of protein production required for this rapid growth is poorly understood. Here we show that the physiological unfolded protein response (UPR) is induced in the highly branched Caenorhabditis elegans sensory neuron PVD during dendrite morphogenesis. Perturbation of the IRE1 arm of the UPR pathway causes loss of dendritic branches, a phenotype that can be rescued by overexpression of the ER chaperone HSP-4 (a homolog of mammalian BiP/grp78). Surprisingly, a single transmembrane leucine-rich repeat protein, DMA-1, plays a major role in the induction of the UPR and the dendritic phenotype in the UPR mutants. These findings reveal a significant role for the physiological UPR in the maintenance of ER homeostasis during morphogenesis of large dendritic arbors.
巻・号 4
ページ e06963
公開日 2015-6-8
DOI 10.7554/eLife.06963
PMID 26052671
PMC PMC4484204
MeSH Animals Caenorhabditis elegans / growth & development* Caenorhabditis elegans Proteins / metabolism Dendrites / physiology* Endoribonucleases / genetics Endoribonucleases / metabolism Membrane Proteins / metabolism Morphogenesis* Protein Biosynthesis* Unfolded Protein Response*
IF 7.08
引用数 20
WOS 分野 BIOLOGY
リソース情報
線虫 tm2482