論文 - 詳細
| RRC ID | 432 |
|---|---|
| 著者 | Cardoso C, Couillault C, Mignon-Ravix C, Millet A, Ewbank JJ, Fontés M, Pujol N. |
| タイトル | XNP-1/ATR-X acts with RB, HP1 and the NuRD complex during larval development in C. elegans. |
| ジャーナル | Dev Biol |
| Abstract |
Mutations in the XNP/ATR-X gene cause several X-linked mental retardation syndromes in humans. The XNP/ATR-X gene encodes a DNA-helicase belonging to the SNF2 family. It has been proposed that XNP/ATR-X might be involved in chromatin remodelling. The lack of a mouse model for the ATR-X syndrome has, however, hampered functional studies of XNP/ATR-X. C. elegans possesses one homolog of the XNP/ATR-X gene, named xnp-1. By analysing a deletion mutant, we show that xnp-1 is required for the development of the embryo and the somatic gonad. Moreover, we show that abrogation of xnp-1 function in combination with inactivation of genes of the NuRD complex, as well as lin-35/Rb and hpl-2/HP1 leads to a stereotyped block of larval development with a cessation of growth but not of cell division. We also demonstrate a specific function for xnp-1 together with lin-35 or hpl-2 in the control of transgene expression, a process known to be dependent on chromatin remodelling. This study thus demonstrates that in vivo XNP-1 acts in association with RB, HP1 and the NuRD complex during development. |
| 巻・号 | 278(1) |
| ページ | 49-59 |
| 公開日 | 2005-2-1 |
| DOI | 10.1016/j.ydbio.2004.10.014 |
| PII | S0012-1606(04)00747-X |
| PMID | 15649460 |
| MeSH | Animals Animals, Genetically Modified Caenorhabditis elegans / genetics Caenorhabditis elegans / growth & development* Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / physiology DNA Helicases / genetics DNA Helicases / physiology DNA-Binding Proteins / genetics DNA-Binding Proteins / physiology Genes, Helminth Gonads / growth & development Helminth Proteins / genetics Helminth Proteins / physiology* Hepatocyte Nuclear Factor 1 Hepatocyte Nuclear Factor 1-alpha Histone Deacetylases / genetics Histone Deacetylases / physiology Humans Larva / growth & development Mi-2 Nucleosome Remodeling and Deacetylase Complex Mutation Nuclear Proteins / genetics Nuclear Proteins / physiology RNA Interference Retinoblastoma Protein / genetics Retinoblastoma Protein / physiology Transcription Factors / genetics Transcription Factors / physiology |
| IF | 2.896 |
| 引用数 | 25 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY |
| リソース情報 | |
| 線虫 | tm678 |