RRC ID |
4292
|
著者 |
Seidel HS, Rockman MV, Kruglyak L.
|
タイトル |
Widespread genetic incompatibility in C. elegans maintained by balancing selection.
|
ジャーナル |
Science
|
Abstract |
Natural selection is expected to eliminate genetic incompatibilities from interbreeding populations. We have discovered a globally distributed incompatibility in the primarily selfing species Caenorhabditis elegans that has been maintained despite its negative consequences for fitness. Embryos homozygous for a naturally occurring deletion of the zygotically acting gene zeel-1 arrest if their sperm parent carries an incompatible allele of a second, paternal-effect locus, peel-1. The two interacting loci are tightly linked, with incompatible alleles occurring in linkage disequilibrium in two common haplotypes. These haplotypes exhibit elevated sequence divergence, and population genetic analyses of this region indicate that natural selection is preserving both haplotypes in the population. Our data suggest that long-term maintenance of a balanced polymorphism has permitted the incompatibility to persist despite gene flow across the rest of the genome.
|
巻・号 |
319(5863)
|
ページ |
589-94
|
公開日 |
2008-2-1
|
DOI |
10.1126/science.1151107
|
PII |
1151107
|
PMID |
18187622
|
PMC |
PMC2421010
|
MeSH |
Alleles
Animals
Animals, Genetically Modified
Caenorhabditis elegans / embryology
Caenorhabditis elegans / genetics*
Cloning, Molecular
Crosses, Genetic
Disorders of Sex Development
Embryo, Nonmammalian / physiology
Embryonic Development
Gene Flow
Genes, Helminth
Genetic Linkage
Genome, Helminth
Haplotypes
Linkage Disequilibrium
Male
Molecular Sequence Data
Penetrance
Polymorphism, Single Nucleotide
Selection, Genetic*
|
IF |
41.846
|
引用数 |
156
|
WOS 分野
|
GENETICS & HEREDITY
|
リソース情報 |
線虫 |
tm1946 |