RRC ID 4292
著者 Seidel HS, Rockman MV, Kruglyak L.
タイトル Widespread genetic incompatibility in C. elegans maintained by balancing selection.
ジャーナル Science
Abstract Natural selection is expected to eliminate genetic incompatibilities from interbreeding populations. We have discovered a globally distributed incompatibility in the primarily selfing species Caenorhabditis elegans that has been maintained despite its negative consequences for fitness. Embryos homozygous for a naturally occurring deletion of the zygotically acting gene zeel-1 arrest if their sperm parent carries an incompatible allele of a second, paternal-effect locus, peel-1. The two interacting loci are tightly linked, with incompatible alleles occurring in linkage disequilibrium in two common haplotypes. These haplotypes exhibit elevated sequence divergence, and population genetic analyses of this region indicate that natural selection is preserving both haplotypes in the population. Our data suggest that long-term maintenance of a balanced polymorphism has permitted the incompatibility to persist despite gene flow across the rest of the genome.
巻・号 319(5863)
ページ 589-94
公開日 2008-2-1
DOI 10.1126/science.1151107
PII 1151107
PMID 18187622
PMC PMC2421010
MeSH Alleles Animals Animals, Genetically Modified Caenorhabditis elegans / embryology Caenorhabditis elegans / genetics* Cloning, Molecular Crosses, Genetic Disorders of Sex Development Embryo, Nonmammalian / physiology Embryonic Development Gene Flow Genes, Helminth Genetic Linkage Genome, Helminth Haplotypes Linkage Disequilibrium Male Molecular Sequence Data Penetrance Polymorphism, Single Nucleotide Selection, Genetic*
IF 41.846
引用数 156
WOS 分野 GENETICS & HEREDITY
リソース情報
線虫 tm1946