RRC ID 4286
著者 Reiner DJ, Ailion M, Thomas JH, Meyer BJ.
タイトル C. elegans anaplastic lymphoma kinase ortholog SCD-2 controls dauer formation by modulating TGF-beta signaling.
ジャーナル Curr Biol
Abstract BACKGROUND:Different environmental stimuli, including exposure to dauer pheromone, food deprivation, and high temperature, can induce C. elegans larvae to enter the dauer stage, a developmentally arrested diapause state. Although molecular and cellular pathways responsible for detecting dauer pheromone and temperature have been defined in part, other sensory inputs are poorly understood, as are the mechanisms by which these diverse sensory inputs are integrated to achieve a consistent developmental outcome.
RESULTS:In this paper, we analyze a wild C. elegans strain isolated from a desert oasis. Unlike wild-type laboratory strains, the desert strain fails to respond to dauer pheromone at 25 degrees C, but it does respond at higher temperatures, suggesting a unique adaptation to the hot desert environment. We map this defect in dauer response to a mutation in the scd-2 gene, which, we show, encodes the nematode anaplastic lymphoma kinase (ALK) homolog, a proto-oncogene receptor tyrosine kinase. scd-2 acts in a genetic pathway shown here to include the HEN-1 ligand, the RTK adaptor SOC-1, and the MAP kinase SMA-5. The SCD-2 pathway modulates TGF-beta signaling, which mediates the response to dauer pheromone, but SCD-2 might mediate a nonpheromone sensory input, such as food.
CONCLUSIONS:Our studies identify a new sensory pathway controlling dauer formation and shed light on ALK signaling, integration of signaling pathways, and adaptation to extreme environmental conditions.
巻・号 18(15)
ページ 1101-9
公開日 2008-8-5
DOI 10.1016/j.cub.2008.06.060
PII S0960-9822(08)00817-8
PMID 18674914
PMC PMC3489285
MeSH Adaptation, Biological Animals Caenorhabditis elegans / enzymology* Caenorhabditis elegans / genetics Caenorhabditis elegans / physiology Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism Caenorhabditis elegans Proteins / physiology* Desert Climate Feeding Behavior Ligands Mutation Nerve Tissue Proteins / genetics Nerve Tissue Proteins / metabolism Phenotype Pheromones / metabolism Protein-Tyrosine Kinases / genetics Protein-Tyrosine Kinases / metabolism Protein-Tyrosine Kinases / physiology* Signal Transduction* Smad Proteins / genetics Smad Proteins / metabolism Transforming Growth Factor beta / metabolism*
IF 9.601
引用数 39
WOS 分野 BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY
リソース情報
線虫 tm501