RRC ID 4238
著者 Hatzold J, Conradt B.
タイトル Control of apoptosis by asymmetric cell division.
ジャーナル PLoS Biol
Abstract Asymmetric cell division and apoptosis (programmed cell death) are two fundamental processes that are important for the development and function of multicellular organisms. We have found that the processes of asymmetric cell division and apoptosis can be functionally linked. Specifically, we show that asymmetric cell division in the nematode Caenorhabditis elegans is mediated by a pathway involving three genes, dnj-11 MIDA1, ces-2 HLF, and ces-1 Snail, that directly control the enzymatic machinery responsible for apoptosis. Interestingly, the MIDA1-like protein GlsA of the alga Volvox carteri, as well as the Snail-related proteins Snail, Escargot, and Worniu of Drosophila melanogaster, have previously been implicated in asymmetric cell division. Therefore, C. elegans dnj-11 MIDA1, ces-2 HLF, and ces-1 Snail may be components of a pathway involved in asymmetric cell division that is conserved throughout the plant and animal kingdoms. Furthermore, based on our results, we propose that this pathway directly controls the apoptotic fate in C. elegans, and possibly other animals as well.
巻・号 6(4)
ページ e84
公開日 2008-4-8
DOI 10.1371/journal.pbio.0060084
PII 07-PLBI-RA-2604
PMID 18399720
PMC PMC2288629
MeSH Animals Animals, Genetically Modified Apoptosis* Basic-Leucine Zipper Transcription Factors / genetics Basic-Leucine Zipper Transcription Factors / metabolism Caenorhabditis elegans / metabolism Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Cell Death Cell Division* DNA-Binding Proteins / genetics DNA-Binding Proteins / metabolism Genes, Helminth Heat-Shock Proteins / genetics Phenotype Signal Transduction Transcription Factors / genetics Transcription Factors / metabolism
IF 7.076
引用数 47
WOS 分野 BIOLOGY BIOCHEMISTRY & MOLECULAR BIOLOGY
リソース情報
線虫 tm2859