RRC ID 4211
著者 Bendena WG, Boudreau JR, Papanicolaou T, Maltby M, Tobe SS, Chin-Sang ID.
タイトル A Caenorhabditis elegans allatostatin/galanin-like receptor NPR-9 inhibits local search behavior in response to feeding cues.
ジャーナル Proc Natl Acad Sci U S A
Abstract Movement in Caenorhabditis elegans is the result of sensory cues creating stimulatory and inhibitory output from sensory neurons. Four interneurons (AIA, AIB, AIY, and AIZ) are the primary recipients of this information that is further processed en route to motor neurons and muscle contraction. C. elegans has >1,000 G protein-coupled receptors (GPCRs), and their contribution to sensory-based movement is largely undefined. We show that an allatostatin/galanin-like GPCR (NPR-9) is found exclusively in the paired AIB interneuron. AIB interneurons are associated with local search/pivoting behavior. npr-9 mutants display an increased local search/pivoting that impairs their ability to roam and travel long distances on food. With impaired roaming behavior on food npr-9 mutants accumulate more intestinal fat as compared with wild type. Overexpression of NPR-9 resulted in a gain-of-function phenotype that exhibits enhanced forward movement with lost pivoting behavior off food. As such the animal travels a great distance off food, creating arcs to return to food. These findings indicate that NPR-9 has inhibitory effects on the AIB interneuron to regulate foraging behavior, which, in turn, may affect metabolic rate and lipid storage.
巻・号 105(4)
ページ 1339-42
公開日 2008-1-29
DOI 10.1073/pnas.0709492105
PII 0709492105
PMID 18216257
PMC PMC2234139
MeSH Animals Animals, Genetically Modified Appetitive Behavior* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / physiology* Cues* Feeding Behavior* Galanin-Like Peptide / physiology Immobilization* Interneurons / metabolism Interneurons / physiology Locomotion* Neuropeptides / physiology Receptors, Galanin / physiology* Receptors, Neuropeptide Y / genetics Receptors, Neuropeptide Y / physiology*
IF 9.412
引用数 41
WOS 分野 BIOCHEMISTRY & MOLECULAR BIOLOGY
リソース情報
線虫 tm1652