論文 - 詳細
| RRC ID | 4190 |
|---|---|
| 著者 | Tarailo M, Tarailo S, Rose AM. |
| タイトル | Synthetic lethal interactions identify phenotypic "interologs" of the spindle assembly checkpoint components. |
| ジャーナル | Genetics |
| Abstract |
Here, we report genetic interactions with mdf-1(gk2)/MAD1 in Caenorhabditis elegans. Nine are evolutionarily conserved or phenotypic "interologs" and two are novel enhancers, hcp-1 and bub-3. We show that HCP-1 and HCP-2, the two CENP-F-related proteins, recently implicated in the spindle assembly checkpoint (SAC) function, do not have identical functions, since hcp-1(RNAi), but not hcp-2(RNAi), enhances the lethality of the SAC mutants. |
| 巻・号 | 177(4) |
| ページ | 2525-30 |
| 公開日 | 2007-12-1 |
| DOI | 10.1534/genetics.107.080408 |
| PII | 177/4/2525 |
| PMID | 18073444 |
| PMC | PMC2219473 |
| MeSH | Animals Caenorhabditis elegans / genetics Caenorhabditis elegans Proteins / genetics* Cell Cycle Proteins / genetics* Chromosomal Proteins, Non-Histone / genetics* Gene Regulatory Networks Nuclear Proteins Phenotype Spindle Apparatus / genetics* |
| IF | 4.015 |
| 引用数 | 32 |
| WOS 分野 | GENETICS & HEREDITY |
| リソース情報 | |
| 線虫 | tm2910 tm2815 |