論文 - 詳細
RRC ID | 40027 |
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著者 | Li X, Wang Y, Wang H, Liu T, Guo J, Yi W, Li Y. |
タイトル | Epithelia-derived wingless regulates dendrite directional growth of drosophila ddaE neuron through the Fz-Fmi-Dsh-Rac1 pathway. |
ジャーナル | Mol Brain |
Abstract |
BACKGROUND:Proper dendrite patterning is critical for the receiving and processing of information in the nervous system. Cell-autonomous molecules have been extensively studied in dendrite morphogenesis; however, the regulatory mechanisms of environmental factors in dendrite growth remain to be elucidated. RESULTS:By evaluating the angle between two primary dendrites (PD-Angle), we found that the directional growth of the primary dendrites of a Drosophila periphery sensory neuron ddaE is regulated by the morphogen molecule Wingless (Wg). During the early stage of dendrite growth, Wg is expressed in a group of epithelial cells posteriorly adjacent to ddaE. When Wg expression is reduced or shifted anteriorly, the PD-Angle is markedly decreased. Furthermore, Wg receptor Frizzled functions together with Flamingo and Dishevelled in transducing the Wg signal into ddaE neuron, and the downstream signal is mediated by non-canonical Wnt pathway through Rac1. CONCLUSIONS:In conclusion, we reveal that epithelia-derived Wg plays a repulsive role in regulating the directional growth of dendrites through the non-canonical Wnt pathway. Thus, our findings provide strong in vivo evidence on how environmental signals serve as spatial cues for dendrite patterning. |
巻・号 | 9(1) |
ページ | 46 |
公開日 | 2016-4-29 |
DOI | 10.1186/s13041-016-0228-0 |
PII | 10.1186/s13041-016-0228-0 |
PMID | 27129721 |
PMC | PMC4850637 |
MeSH | Animals Dendrites / metabolism* Down-Regulation Drosophila Proteins / metabolism* Drosophila melanogaster / metabolism* Epithelium / metabolism* Mutation / genetics Signal Transduction* Wnt1 Protein / metabolism* |
IF | 4.686 |
引用数 | 1 |
WOS 分野 | NEUROSCIENCES |
リソース情報 | |
ショウジョウバエ | 11579R-2 |