RRC ID 40027
著者 Li X, Wang Y, Wang H, Liu T, Guo J, Yi W, Li Y.
タイトル Epithelia-derived wingless regulates dendrite directional growth of drosophila ddaE neuron through the Fz-Fmi-Dsh-Rac1 pathway.
ジャーナル Mol Brain
Abstract BACKGROUND:Proper dendrite patterning is critical for the receiving and processing of information in the nervous system. Cell-autonomous molecules have been extensively studied in dendrite morphogenesis; however, the regulatory mechanisms of environmental factors in dendrite growth remain to be elucidated.
RESULTS:By evaluating the angle between two primary dendrites (PD-Angle), we found that the directional growth of the primary dendrites of a Drosophila periphery sensory neuron ddaE is regulated by the morphogen molecule Wingless (Wg). During the early stage of dendrite growth, Wg is expressed in a group of epithelial cells posteriorly adjacent to ddaE. When Wg expression is reduced or shifted anteriorly, the PD-Angle is markedly decreased. Furthermore, Wg receptor Frizzled functions together with Flamingo and Dishevelled in transducing the Wg signal into ddaE neuron, and the downstream signal is mediated by non-canonical Wnt pathway through Rac1.
CONCLUSIONS:In conclusion, we reveal that epithelia-derived Wg plays a repulsive role in regulating the directional growth of dendrites through the non-canonical Wnt pathway. Thus, our findings provide strong in vivo evidence on how environmental signals serve as spatial cues for dendrite patterning.
巻・号 9(1)
ページ 46
公開日 2016-4-29
DOI 10.1186/s13041-016-0228-0
PII 10.1186/s13041-016-0228-0
PMID 27129721
PMC PMC4850637
MeSH Animals Dendrites / metabolism* Down-Regulation Drosophila Proteins / metabolism* Drosophila melanogaster / metabolism* Epithelium / metabolism* Mutation / genetics Signal Transduction* Wnt1 Protein / metabolism*
IF 4.686
引用数 1
WOS 分野 NEUROSCIENCES
リソース情報
ショウジョウバエ 11579R-2