論文 - 詳細
| RRC ID | 3568 |
|---|---|
| 著者 | Chuang CF, Vanhoven MK, Fetter RD, Verselis VK, Bargmann CI. |
| タイトル | An innexin-dependent cell network establishes left-right neuronal asymmetry in C. elegans. |
| ジャーナル | Cell |
| Abstract |
Gap junctions are widespread in immature neuronal circuits, but their functional significance is poorly understood. We show here that a transient network formed by the innexin gap-junction protein NSY-5 coordinates left-right asymmetry in the developing nervous system of Caenorhabditis elegans. nsy-5 is required for the left and right AWC olfactory neurons to establish stochastic, asymmetric patterns of gene expression during embryogenesis. nsy-5-dependent gap junctions in the embryo transiently connect the AWC cell bodies with those of numerous other neurons. Both AWCs and several other classes of nsy-5-expressing neurons participate in signaling that coordinates left-right AWC asymmetry. The right AWC can respond to nsy-5 directly, but the left AWC requires nsy-5 function in multiple cells of the network. NSY-5 forms hemichannels and intercellular gap-junction channels in Xenopus oocytes, consistent with a combination of cell-intrinsic and network functions. These results provide insight into gap-junction activity in developing circuits. |
| 巻・号 | 129(4) |
| ページ | 787-99 |
| 公開日 | 2007-5-18 |
| DOI | 10.1016/j.cell.2007.02.052 |
| PII | S0092-8674(07)00451-5 |
| PMID | 17512411 |
| MeSH | Amino Acid Sequence Animals Base Sequence Body Patterning / physiology* Caenorhabditis elegans / embryology* Caenorhabditis elegans / metabolism Caenorhabditis elegans / ultrastructure Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / isolation & purification Caenorhabditis elegans Proteins / metabolism* Calcium Signaling / physiology Cell Communication / physiology Cell Differentiation / physiology Connexins / genetics Connexins / isolation & purification Connexins / metabolism* Functional Laterality / physiology Gap Junctions / metabolism Membrane Proteins / metabolism Molecular Sequence Data Nerve Net / embryology* Nerve Net / metabolism Nerve Net / ultrastructure Nervous System / embryology* Nervous System / metabolism Nervous System / ultrastructure Neurons / metabolism* Neurons / ultrastructure Olfactory Pathways / embryology Olfactory Pathways / metabolism Olfactory Pathways / ultrastructure |
| IF | 38.637 |
| 引用数 | 91 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| リソース情報 | |
| 線虫 | tm1896 |