RRC ID 3545
著者 Shakir MA, Gill JS, Lundquist EA.
タイトル Interactions of UNC-34 Enabled with Rac GTPases and the NIK kinase MIG-15 in Caenorhabditis elegans axon pathfinding and neuronal migration.
ジャーナル Genetics
Abstract Many genes that affect axon pathfinding and cell migration have been identified. Mechanisms by which these genes and the molecules they encode interact with one another in pathways and networks to control developmental events are unclear. Rac GTPases, the cytoskeletal signaling molecule Enabled, and NIK kinase have all been implicated in regulating axon pathfinding and cell migration. Here we present evidence that, in Caenorhabditis elegans, three Rac GTPases, CED-10, RAC-2, and MIG-2, define three redundant pathways that each control axon pathfinding, and that the NIK kinase MIG-15 acts in each Rac pathway. Furthermore, we show that the Enabled molecule UNC-34 defines a fourth partially redundant pathway that acts in parallel to Rac/MIG-15 signaling in axon pathfinding. Enabled and the three Racs also act redundantly to mediate AQR and PQR neuronal cell migration. The Racs and UNC-34 Ena might all control the formation of actin-based protrusive structures (lamellipodia and filopodia) that mediate growth cone outgrowth and cell migration. MIG-15 does not act with the three Racs in execution of cell migration. Rather, MIG-15 affects direction of PQR neuronal migration, similar to UNC-40 and DPY-19, which control initial Q cell polarity, and Wnt signaling, which acts later to control Q cell-directed migration. MIG-2 Rac, which acts with CED-10 Rac, RAC-2 Rac, and UNC-34 Ena in axon pathfinding and cell migration, also acts with MIG-15 in PQR directional migration.
巻・号 172(2)
ページ 893-913
公開日 2006-2-1
DOI 10.1534/genetics.105.046359
PII genetics.105.046359
PMID 16204220
PMC PMC1456253
MeSH Alleles Amino Acid Sequence Animals Axons / enzymology Axons / physiology* Base Sequence Caenorhabditis elegans / enzymology Caenorhabditis elegans / growth & development Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Cell Movement / genetics Cell Movement / physiology* Molecular Sequence Data Nerve Tissue Proteins / genetics Nerve Tissue Proteins / metabolism* Neurons / cytology* Neurons / enzymology Neurons / metabolism Protein Serine-Threonine Kinases / metabolism* Signal Transduction / genetics Signal Transduction / physiology rac GTP-Binding Proteins / genetics rac GTP-Binding Proteins / metabolism*
IF 4.015
引用数 49
WOS 分野 GENETICS & HEREDITY
リソース情報
線虫 tm597