RRC ID 34895
著者 Ewald CY, Landis JN, Porter Abate J, Murphy CT, Blackwell TK.
タイトル Dauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevity.
ジャーナル Nature
Abstract Interventions that delay ageing mobilize mechanisms that protect and repair cellular components, but it is unknown how these interventions might slow the functional decline of extracellular matrices, which are also damaged during ageing. Reduced insulin/IGF-1 signalling (rIIS) extends lifespan across the evolutionary spectrum, and in juvenile Caenorhabditis elegans also allows the transcription factor DAF-16/FOXO to induce development into dauer, a diapause that withstands harsh conditions. It has been suggested that rIIS delays C. elegans ageing through activation of dauer-related processes during adulthood, but some rIIS conditions confer robust lifespan extension unaccompanied by any dauer-like traits. Here we show that rIIS can promote C. elegans longevity through a program that is genetically distinct from the dauer pathway, and requires the Nrf (NF-E2-related factor) orthologue SKN-1 acting in parallel to DAF-16. SKN-1 is inhibited by IIS and has been broadly implicated in longevity, but is rendered dispensable for rIIS lifespan extension by even mild activity of dauer-related processes. When IIS is decreased under conditions that do not induce dauer traits, SKN-1 most prominently increases expression of collagens and other extracellular matrix genes. Diverse genetic, nutritional, and pharmacological pro-longevity interventions delay an age-related decline in collagen expression. These collagens mediate adulthood extracellular matrix remodelling, and are needed for ageing to be delayed by interventions that do not involve dauer traits. By genetically delineating a dauer-independent rIIS ageing pathway, our results show that IIS controls a broad set of protective mechanisms during C. elegans adulthood, and may facilitate elucidation of processes of general importance for longevity. The importance of collagen production in diverse anti-ageing interventions implies that extracellular matrix remodelling is a generally essential signature of longevity assurance, and that agents promoting extracellular matrix youthfulness may have systemic benefit.
巻・号 519(7541)
ページ 97-101
公開日 2015-3-5
DOI 10.1038/nature14021
PII nature14021
PMID 25517099
PMC PMC4352135
MeSH Aging / physiology Animals Caenorhabditis elegans / growth & development Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / metabolism* Collagen / biosynthesis Collagen / genetics Collagen / metabolism* DNA-Binding Proteins / metabolism* Extracellular Matrix / metabolism Forkhead Transcription Factors Insulin / metabolism* Insulin-Like Growth Factor I / metabolism* Larva / growth & development Longevity / physiology* Signal Transduction* Transcription Factors / metabolism*
IF 42.779
引用数 108
WOS 分野 BIOCHEMISTRY & MOLECULAR BIOLOGY
リソース情報
線虫 skn-1(tm3411) tm1817