論文 - 詳細
| RRC ID | 3439 |
|---|---|
| 著者 | Kodama E, Kuhara A, Mohri-Shiomi A, Kimura KD, Okumura M, Tomioka M, Iino Y, Mori I. |
| タイトル | Insulin-like signaling and the neural circuit for integrative behavior in C. elegans. |
| ジャーナル | Genes Dev |
| Abstract |
Caenorhabditis elegans exhibits a food-associated behavior that is modulated by the past cultivation temperature. Mutations in INS-1, the homolog of human insulin, caused the defect in this integrative behavior. Mutations in DAF-2/insulin receptor and AGE-1/phosphatidylinositol 3 (PI-3)-kinase partially suppressed the defect of ins-1 mutants, and a mutation in DAF-16, a forkhead-type transcriptional factor, caused a weak defect. In addition, mutations in the secretory protein HEN-1 showed synergistic effects with INS-1. Expression of AGE-1 in any of the three interneurons, AIY, AIZ, or RIA, rescued the defect characteristic of age-1 mutants. Calcium imaging revealed that starvation induced INS-1-mediated down-regulation of AIZ activity. Our results suggest that INS-1, in cooperation with HEN-1, antagonizes the DAF-2 insulin-like signaling pathway to modulate interneuron activity required for food-associated integrative behavior. |
| 巻・号 | 20(21) |
| ページ | 2955-60 |
| 公開日 | 2006-11-1 |
| DOI | 10.1101/gad.1479906 |
| PII | 20/21/2955 |
| PMID | 17079685 |
| PMC | PMC1620028 |
| MeSH | Animals Caenorhabditis elegans / genetics Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / antagonists & inhibitors* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Feeding Behavior* Insulin / genetics Insulin / metabolism* Mutation Nerve Tissue Proteins / genetics Nerve Tissue Proteins / metabolism* Neurons / physiology* Phosphatidylinositol 3-Kinases / genetics Phosphatidylinositol 3-Kinases / metabolism Receptor, Insulin / antagonists & inhibitors* Receptor, Insulin / genetics Signal Transduction Suppression, Genetic Temperature |
| IF | 9.527 |
| 引用数 | 76 |
| WOS 分野 | GENETICS & HEREDITY DEVELOPMENTAL BIOLOGY CELL BIOLOGY |
| リソース情報 | |
| 線虫 | tm501 |