RRC ID 3375
著者 Bhalla N, Dernburg AF.
タイトル A conserved checkpoint monitors meiotic chromosome synapsis in Caenorhabditis elegans.
ジャーナル Science
Abstract We report the discovery of a checkpoint that monitors synapsis between homologous chromosomes to ensure accurate meiotic segregation. Oocytes containing unsynapsed chromosomes selectively undergo apoptosis even if a germline DNA damage checkpoint is inactivated. This culling mechanism is specifically activated by unsynapsed pairing centers, cis-acting chromosome sites that are also required to promote synapsis in Caenorhabditis elegans. Apoptosis due to synaptic failure also requires the C. elegans homolog of PCH2, a budding yeast pachytene checkpoint gene, which suggests that this surveillance mechanism is widely conserved.
巻・号 310(5754)
ページ 1683-6
公開日 2005-12-9
DOI 10.1126/science.1117468
PII 310/5754/1683
PMID 16339446
MeSH Animals Apoptosis Caenorhabditis elegans / genetics Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / physiology Chromosome Pairing / physiology* Chromosome Segregation Disorders of Sex Development Female Genes, Helminth Male Meiosis* Mutation Oocytes / physiology Recombination, Genetic Transgenes X Chromosome / genetics X Chromosome / physiology
IF 41.846
引用数 132
WOS 分野 CELL BIOLOGY
リソース情報
線虫 tm1458