RRC ID |
31351
|
著者 |
Taneda Y, Konno S, Makino S, Morioka M, Fukuda K, Imai Y, Kudo A, Kawakami A.
|
タイトル |
Epigenetic control of cardiomyocyte production in response to a stress during the medaka heart development.
|
ジャーナル |
Dev Biol
|
Abstract |
The size and morphology of organs are largely determined by a genetic program. However in some cases, an epigenetic mechanism influences the process of organ development. Particularly, epigenetic factors such as hemodynamic stress and blood pressure affect the morphogenesis of cardiac chambers and valves. Here, we report that the epigenetic influences affect the cardiomyocyte production. Taking advantage of longer developmental period of medaka fish, we could examine the later emerging tissue responses to the defect of ventricular beating, which occurred in the hozuki (hoz) mutant that harbors the mutated ventricular myosin heavy chain (vmhc) gene. The mutant showed a remarkable ventricular enlargement, and we showed that this enlargement was due to an excess production of ventricular cardiomyocytes in addition to the lack of concentric chamber growth. By experimental blockade of blood flow, we demonstrated that an elevated cardiac pressure was responsible for the aberrant cardiomyocyte production. From these data, we propose that the epigenetic tissue response to a stressed situation controls the production of cardiomyocytes to attain a fine tuning of heart formation.
|
巻・号 |
340(1)
|
ページ |
30-40
|
公開日 |
2010-4-1
|
DOI |
10.1016/j.ydbio.2010.01.014
|
PII |
S0012-1606(10)00031-X
|
PMID |
20096279
|
MeSH |
Animals
Animals, Genetically Modified
Body Patterning
Cardiac Myosins / genetics
Cardiac Myosins / metabolism
Embryo, Nonmammalian / metabolism*
Epigenesis, Genetic*
Gene Expression Regulation, Developmental*
Heart Ventricles / metabolism
Mutation
Myocardium / metabolism
Myocytes, Cardiac / cytology
Myocytes, Cardiac / metabolism*
Myosin Heavy Chains / genetics
Myosin Heavy Chains / metabolism
Oryzias / embryology*
Oryzias / genetics
|
IF |
2.896
|
引用数 |
9
|
WOS 分野
|
DEVELOPMENTAL BIOLOGY
|
リソース情報 |
メダカ |
MT322 (ki17
hozuki)
TG1026 (Cab-Tg(zfmlc2 5.1k: DsRed2-nuc) )
TG889 (Tg(zfmlc2 5.1k: DsRed2-nuc)) |