RRC ID 31351
著者 Taneda Y, Konno S, Makino S, Morioka M, Fukuda K, Imai Y, Kudo A, Kawakami A.
タイトル Epigenetic control of cardiomyocyte production in response to a stress during the medaka heart development.
ジャーナル Dev Biol
Abstract The size and morphology of organs are largely determined by a genetic program. However in some cases, an epigenetic mechanism influences the process of organ development. Particularly, epigenetic factors such as hemodynamic stress and blood pressure affect the morphogenesis of cardiac chambers and valves. Here, we report that the epigenetic influences affect the cardiomyocyte production. Taking advantage of longer developmental period of medaka fish, we could examine the later emerging tissue responses to the defect of ventricular beating, which occurred in the hozuki (hoz) mutant that harbors the mutated ventricular myosin heavy chain (vmhc) gene. The mutant showed a remarkable ventricular enlargement, and we showed that this enlargement was due to an excess production of ventricular cardiomyocytes in addition to the lack of concentric chamber growth. By experimental blockade of blood flow, we demonstrated that an elevated cardiac pressure was responsible for the aberrant cardiomyocyte production. From these data, we propose that the epigenetic tissue response to a stressed situation controls the production of cardiomyocytes to attain a fine tuning of heart formation.
巻・号 340(1)
ページ 30-40
公開日 2010-4-1
DOI 10.1016/j.ydbio.2010.01.014
PII S0012-1606(10)00031-X
PMID 20096279
MeSH Animals Animals, Genetically Modified Body Patterning Cardiac Myosins / genetics Cardiac Myosins / metabolism Embryo, Nonmammalian / metabolism* Epigenesis, Genetic* Gene Expression Regulation, Developmental* Heart Ventricles / metabolism Mutation Myocardium / metabolism Myocytes, Cardiac / cytology Myocytes, Cardiac / metabolism* Myosin Heavy Chains / genetics Myosin Heavy Chains / metabolism Oryzias / embryology* Oryzias / genetics
IF 2.896
引用数 9
WOS 分野 DEVELOPMENTAL BIOLOGY
リソース情報
メダカ MT322 (ki17 hozuki) TG1026 (Cab-Tg(zfmlc2 5.1k: DsRed2-nuc) ) TG889 (Tg(zfmlc2 5.1k: DsRed2-nuc))