| RRC ID |
30652
|
| 著者 |
Salzberg Y, Díaz-Balzac CA, Ramirez-Suarez NJ, Attreed M, Tecle E, Desbois M, Kaprielian Z, Bülow HE.
|
| タイトル |
Skin-derived cues control arborization of sensory dendrites in Caenorhabditis elegans.
|
| ジャーナル |
Cell
|
| Abstract |
Sensory dendrites depend on cues from their environment to pattern their growth and direct them toward their correct target tissues. Yet, little is known about dendrite-substrate interactions during dendrite morphogenesis. Here, we describe MNR-1/menorin, which is part of the conserved Fam151 family of proteins and is expressed in the skin to control the elaboration of "menorah"-like dendrites of mechanosensory neurons in Caenorhabditis elegans. We provide biochemical and genetic evidence that MNR-1 acts as a contact-dependent or short-range cue in concert with the neural cell adhesion molecule SAX-7/L1CAM in the skin and through the neuronal leucine-rich repeat transmembrane receptor DMA-1 on sensory dendrites. Our data describe an unknown pathway that provides spatial information from the skin substrate to pattern sensory dendrite development nonautonomously.
|
| 巻・号 |
155(2)
|
| ページ |
308-20
|
| 公開日 |
2013-10-10
|
| DOI |
10.1016/j.cell.2013.08.058
|
| PII |
S0092-8674(13)01089-1
|
| PMID |
24120132
|
| PMC |
PMC3881433
|
| MeSH |
Amino Acid Sequence
Animals
Caenorhabditis elegans / metabolism*
Caenorhabditis elegans Proteins / genetics
Caenorhabditis elegans Proteins / metabolism*
Cloning, Molecular
Dendrites / metabolism*
Gene Knockdown Techniques
Membrane Proteins / genetics
Membrane Proteins / metabolism*
Molecular Sequence Data
Neurons / metabolism*
Sequence Alignment
|
| IF |
38.637
|
| 引用数 |
73
|
|
WOS 分野
|
BIOCHEMISTRY & MOLECULAR BIOLOGY
CELL BIOLOGY
|
| リソース情報 |
| 線虫 |
tm5159
tm3056 |
