RRC ID 30644
著者 Flavell SW, Pokala N, Macosko EZ, Albrecht DR, Larsch J, Bargmann CI.
タイトル Serotonin and the neuropeptide PDF initiate and extend opposing behavioral states in C. elegans.
ジャーナル Cell
Abstract Foraging animals have distinct exploration and exploitation behaviors that are organized into discrete behavioral states. Here, we characterize a neuromodulatory circuit that generates long-lasting roaming and dwelling states in Caenorhabditis elegans. We find that two opposing neuromodulators, serotonin and the neuropeptide pigment dispersing factor (PDF), each initiate and extend one behavioral state. Serotonin promotes dwelling states through the MOD-1 serotonin-gated chloride channel. The spontaneous activity of serotonergic neurons correlates with dwelling behavior, and optogenetic modulation of the critical MOD-1-expressing targets induces prolonged dwelling states. PDF promotes roaming states through a Gαs-coupled PDF receptor; optogenetic activation of cAMP production in PDF receptor-expressing cells induces prolonged roaming states. The neurons that produce and respond to each neuromodulator form a distributed circuit orthogonal to the classical wiring diagram, with several essential neurons that express each molecule. The slow temporal dynamics of this neuromodulatory circuit supplement fast motor circuits to organize long-lasting behavioral states.
巻・号 154(5)
ページ 1023-1035
公開日 2013-8-29
DOI 10.1016/j.cell.2013.08.001
PII S0092-8674(13)00956-2
PMID 23972393
PMC PMC3942133
MeSH Animals Behavior, Animal Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / metabolism* Chloride Channels / metabolism Cyclic AMP / metabolism Neurons / metabolism Neuropeptides / metabolism* Receptors, G-Protein-Coupled / metabolism Serotonin / metabolism* Signal Transduction*
IF 38.637
引用数 140
WOS 分野 BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY
リソース情報
線虫 tm4393