RRC ID 2877
著者 Shinomiya A, Kato M, Yaezawa M, Sakaizumi M, Hamaguchi S.
タイトル Interspecific hybridization between Oryzias latipes and Oryzias curvinotus causes XY sex reversal.
ジャーナル J Exp Zool A Comp Exp Biol
Abstract The teleost fish, Oryzias curvinotus, is a closely related species to the medaka, Oryzias latipes, and both species have the DMY gene, which is required for male development in O. latipes. It suggests that the molecular function of the DMY gene and the following molecular events of sex differentiation are conserved between these two species. In the present study, we obtained interspecific hybrids between O. curvinotus and O. latipes and demonstrated sex-reversed XY females in the hybrids. The incidence of sex-reversed females in F1 XY hybrids between O. curvinotus females and O. latipes males, and hybrids between O. latipes females and O. curvinotus males were 21% and 100%, respectively. These results indicate that DMY does not always determine maleness in hybrid fish even though it is able to specify normal male development on its native genetic background and suggest that there are some differences between DMY(latipes) and DMY(curvinotus) alleles. Appearance of XY females in F1 hybrids also suggests that an autosomal or X-liked gene(s) from the maternal species interferes in the function of the paternal DMY gene in the male-determining process of the hybrid fish. These hybrid fish would supply a new experimental approach for investigating the genetic and molecular pathway of testis determination and differentiation.
巻・号 305(10)
ページ 890-6
公開日 2006-10-1
DOI 10.1002/jez.a.330
PMID 16941651
MeSH Animals Female Genotype Gonads / anatomy & histology Hermaphroditic Organisms* Hybridization, Genetic* Male Oryzias / genetics* Phenotype Sex Chromosomes / genetics* Sex Determination Processes* Sex Ratio
IF 1.917
引用数 9
WOS 分野 ZOOLOGY
リソース情報
メダカ HdrR-II1 (IB178) O. curvinotus