| RRC ID |
2854
|
| 著者 |
Klüver N, Pfennig F, Pala I, Storch K, Schlieder M, Froschauer A, Gutzeit HO, Schartl M.
|
| タイトル |
Differential expression of anti-Müllerian hormone (amh) and anti-Müllerian hormone receptor type II (amhrII) in the teleost medaka.
|
| ジャーナル |
Dev Dyn
|
| Abstract |
In mammals, the anti-Müllerian hormone (Amh) is responsible for the regression of the Müllerian ducts; therefore, Amh is an important factor of male sex differentiation. The amh gene has been cloned in various vertebrates, as well as in several teleost species. To date, all described species show a sexually dimorphic expression of amh during sex differentiation or at least in differentiated juvenile gonads. We have identified the medaka amh ortholog and examined its expression pattern. Medaka amh shows no sexually dimorphic expression pattern. It is expressed in both developing XY male and XX female gonads. In adult testes, amh is expressed in the Sertoli cells and in adult ovaries in granulosa cells surrounding the oocytes, like in mammals. To better understand the function of amh, we cloned the anti-Müllerian hormone receptor type II (amhrII) ortholog and compared its expression pattern with amh, aromatase (cyp19a1), and scp3. During gonad development, amhrII is coexpressed with medaka amh in somatic cells of the gonads and shows no sexually dimorphic expression. Only the expression level of the Amh type II receptor gene was decreased noticeably in adult female gonads. These results suggest that medaka Amh and AmhrII are involved in gonad formation and maintenance in both sexes.
|
| 巻・号 |
236(1)
|
| ページ |
271-81
|
| 公開日 |
2007-1-1
|
| DOI |
10.1002/dvdy.20997
|
| PMID |
17075875
|
| MeSH |
Amino Acid Sequence
Animals
Anti-Mullerian Hormone
Aromatase / genetics
Aromatase / metabolism
Cloning, Molecular
Female
Fish Proteins / genetics
Fish Proteins / metabolism
Gene Expression Regulation, Developmental
Glycoproteins / genetics*
Glycoproteins / metabolism
Male
Molecular Sequence Data
Oryzias / classification
Oryzias / embryology*
Oryzias / metabolism
Ovary / embryology
Ovary / metabolism
Phylogeny
Receptors, Peptide / genetics*
Receptors, Peptide / metabolism
Receptors, Transforming Growth Factor beta
Sequence Alignment
Testicular Hormones / genetics*
Testicular Hormones / metabolism
Testis / embryology
Testis / metabolism
|
| IF |
3.275
|
| 引用数 |
69
|
|
WOS 分野
|
ANATOMY & MORPHOLOGY
DEVELOPMENTAL BIOLOGY
|
| リソース情報 |
| メダカ |
d-rR
Hd-rR.Y^HNI (MT191)
Qurt (MT828) |
