論文 - 詳細
RRC ID | 21984 |
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著者 | Wu Y, Ren Q, Li H, Guo A. |
タイトル | The GABAergic anterior paired lateral neurons facilitate olfactory reversal learning in Drosophila. |
ジャーナル | Learn Mem |
Abstract |
Reversal learning has been widely used to probe the implementation of cognitive flexibility in the brain. Previous studies in monkeys identified an essential role of the orbitofrontal cortex (OFC) in reversal learning. However, the underlying circuits and molecular mechanisms are poorly understood. Here, we use the T-maze to investigate the neural mechanism of olfactory reversal learning in Drosophila. By adding a reversal training cycle to the classical learning protocol, we show that wild-type flies are able to reverse their choice according to the alteration of conditioned stimulus (CS)-unconditioned stimulus (US) contingency. The reversal protocol induced a specific suppression of the initial memory, an effect distinct from memory decay or extinction. GABA down-regulation in the anterior paired lateral (APL) neurons, which innervate the mushroom bodies (MBs), eliminates this suppression effect and impairs normal reversal. These findings reveal that inhibitory regulation from the GABAergic APL neurons facilitates olfactory reversal learning by suppressing initial memory in Drosophila. |
巻・号 | 19(10) |
ページ | 478-86 |
公開日 | 2012-9-17 |
DOI | 10.1101/lm.025726.112 |
PII | 19/10/478 |
PMID | 22988290 |
MeSH | Animals Animals, Genetically Modified Conditioning, Classical / physiology* Down-Regulation / genetics Drosophila Drosophila Proteins / genetics Drosophila Proteins / metabolism Dynamins / genetics Dynamins / metabolism Extinction, Psychological / physiology GABAergic Neurons / physiology* Glutamate Decarboxylase / genetics Glutamate Decarboxylase / metabolism Lateral Line System / cytology* Lateral Line System / physiology Memory / physiology* Mushroom Bodies / cytology Mushroom Bodies / physiology Mutation / genetics Neural Inhibition / genetics Neural Inhibition / physiology Odorants RNA Interference / physiology Reversal Learning / physiology* Smell / genetics Smell / physiology* Transcription Factors / genetics gamma-Aminobutyric Acid / metabolism |
IF | 2.359 |
引用数 | 22 |
WOS 分野 | PSYCHOLOGY, EXPERIMENTAL NEUROSCIENCES |
リソース情報 | |
ショウジョウバエ | NP225 (DGRC#112095) NP2631 (DGRC#104266) and NP5288 (DGRC#104937) |