RRC ID 20973
著者 Yang YL, Loh KS, Liou BY, Chu IH, Kuo CJ, Chen HD, Chen CS.
タイトル SESN-1 is a positive regulator of lifespan in Caenorhabditis elegans.
ジャーナル Exp Gerontol
Abstract Aging is a process of gradual functional decline leading to death. Reactive oxygen species (ROS) not only contribute to oxidative stress and cell damage that lead to aging but also serve as signaling molecules. Sestrins are evolutionarily conserved in all multicellular organisms and are required for regenerating hyperoxidized forms of peroxiredoxins and ROS clearance. However, whether sestrins regulate longevity in metazoans is still unclear. Here, we demonstrated that SESN-1, the only sestrin ortholog in Caenorhabditis elegans, is a positive regulator of lifespan. sesn-1 gene mutant worms had significantly shorter lifespans compared to wild-type animals, and overexpression of sesn-1 prolonged lifespan. Moreover, sesn-1 was found to play a key role in defense against several life stressors, including heat, hydrogen peroxide and the heavy metal copper; and sesn-1 mutants expressed higher levels of ROS and showed a decline in body muscle function. Surprisingly, loss of sesn-1 did not weaken the innate immune function of the worms. Together, these results suggest that SESN-1 is required for normal lifespan and its function in muscle cells prevents muscle degeneration over a lifetime.
巻・号 48(3)
ページ 371-9
公開日 2013-3-1
DOI 10.1016/j.exger.2012.12.011
PII S0531-5565(13)00008-9
PMID 23318476
MeSH Aging / physiology Animals Animals, Genetically Modified Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / physiology* Heat-Shock Proteins / deficiency Heat-Shock Proteins / genetics Heat-Shock Proteins / physiology* Hot Temperature Immunity, Innate / physiology Locomotion / physiology Longevity / physiology* Muscle Strength / physiology Oxidative Stress / physiology RNA Interference Reactive Oxygen Species / metabolism Stress, Physiological / physiology
IF 3.376
引用数 40
WOS 分野 GERIATRICS & GERONTOLOGY
リソース情報
線虫 tm2872