RRC ID 20957
著者 Nakasone K, Nagahama Y, Okubo K.
タイトル hebp3, a novel member of the heme-binding protein gene family, is expressed in the medaka meninges with higher abundance in females due to a direct stimulating action of ovarian estrogens.
ジャーナル Endocrinology
Abstract The brains of teleost fish exhibit remarkable sexual plasticity throughout their life span. To dissect the molecular basis for the development and reversal of sex differences in the teleost brain, we screened for genes differentially expressed between sexes in the brain of medaka (Oryzias latipes). One of the genes identified in the screen as being preferentially expressed in females was found to be a new member of the heme-binding protein gene family that includes hebp1 and hebp2 and was designated here as hebp3. The medaka hebp3 is expressed in the meninges with higher abundance in females, whereas there is no expression within the brain parenchyma. This female-biased expression of hebp3 is not attributable to the direct action of sex chromosome genes but results from the transient and reversible action of estrogens derived from the ovary. Moreover, estrogens directly activate the transcription of hebp3 via a palindromic estrogen-responsive element in the hebp3 promoter. Taken together, our findings demonstrate that hebp3 is a novel transcriptional target of estrogens, with female-biased expression in the meninges. The definite but reversible sexual dimorphism of the meningeal hebp3 expression may contribute to the development and reversal of sex differences in the teleost brain.
巻・号 154(2)
ページ 920-30
公開日 2013-2-1
DOI 10.1210/en.2012-2000
PII en.2012-2000
PMID 23284102
MeSH Animals Brain / metabolism Carrier Proteins / biosynthesis* Circadian Rhythm Estrogens / pharmacology* Female HeLa Cells Heme-Binding Proteins Hemeproteins / biosynthesis* Humans Meninges / drug effects Meninges / metabolism* Oryzias / metabolism* Ovary / metabolism Promoter Regions, Genetic / genetics Receptors, Estrogen / biosynthesis Sex Characteristics Transcription, Genetic / genetics
IF 3.934
引用数 7
WOS 分野 ENDOCRINOLOGY & METABOLISM
リソース情報
メダカ BAC d-rR/TOKYO (MT837)