RRC ID 15575
著者 Tsuzuki S, Ochiai M, Matsumoto H, Kurata S, Ohnishi A, Hayakawa Y.
タイトル Drosophila growth-blocking peptide-like factor mediates acute immune reactions during infectious and non-infectious stress.
ジャーナル Sci Rep
Abstract Antimicrobial peptides (AMPs), major innate immune effectors, are induced to protect hosts against invading microorganisms. AMPs are also induced under non-infectious stress; however, the signaling pathways of non-infectious stress-induced AMP expression are yet unclear. We demonstrated that growth-blocking peptide (GBP) is a potent cytokine that regulates stressor-induced AMP expression in insects.GBP overexpression in Drosophila elevated expression of AMPs.GBP-induced AMP expression did not require Toll and immune deficiency (Imd) pathway-related genes, but imd and basket were essential,indicating that GBP signaling in Drosophila did not use the orthodox Toll or Imd pathway but used the JNK pathway after association with the adaptor protein Imd. The enhancement of AMP expression by non-infectious physical or environmental stressors was apparent in controls but not in GBP-knockdown larvae. These results indicate that the Drosophila GBP signaling pathway mediates acute innate immune reactions under various stresses, regardless of whether they are infectious or non-infectious.
巻・号 2
ページ 210
公開日 2012-1-5
DOI 10.1038/srep00210
PII srep00210
PMID 22355724
PMC PMC3251627
MeSH Amino Acid Sequence Animals Animals, Genetically Modified Base Sequence Cytokines / chemistry Cytokines / pharmacology* DNA Primers Drosophila / immunology Drosophila / metabolism* Drosophila Proteins / chemistry Drosophila Proteins / pharmacology* Immunity, Innate / physiology* Molecular Sequence Data Sequence Homology, Amino Acid Stress, Physiological*
IF 3.998
引用数 42
WOS 分野 BIOCHEMISTRY & MOLECULAR BIOLOGY
リソース情報
ショウジョウバエ 5680R-1 5680R-2