論文 - 詳細
| RRC ID | 11716 |
|---|---|
| 著者 | Sakurai H, Okado M, Ito F, Kawasaki K. |
| タイトル | Anaphase DNA bridges induced by lack of RecQ5 in Drosophila syncytial embryos. |
| ジャーナル | FEBS Lett |
| Abstract |
Drosophila melanogaster RecQ5, a member of the RecQ family, is expressed in early embryos. The loss of maternally-derived RecQ5 leads to spontaneous mitotic defects in syncytial embryos. We demonstrate that the mitotic defects are derived from anaphase DNA bridges. Pairs of daughter nuclei that had been linked by the bridges concurrently exited from the cycle and were eliminated by Chk2-dependent centrosome inactivation. These results suggest that the lack of RecQ5 leads to spontaneous double-stranded DNA breaks (DSBs). RecQ5 may function in the resolution of anaphase DNA bridges during mitosis or in DSB repair during interphase in syncytial Drosophila embryos. |
| 巻・号 | 585(12) |
| ページ | 1923-8 |
| 公開日 | 2011-6-23 |
| DOI | 10.1016/j.febslet.2011.04.074 |
| PII | S0014-5793(11)00351-6 |
| PMID | 21570978 |
| MeSH | Anaphase / physiology* Animals Checkpoint Kinase 2 DNA / ultrastructure* DNA Breaks, Double-Stranded DNA Helicases Drosophila Proteins / deficiency* Drosophila melanogaster / cytology Drosophila melanogaster / embryology* Drosophila melanogaster / metabolism* Embryo, Nonmammalian / cytology* Giant Cells Mitosis Protein Serine-Threonine Kinases RecQ Helicases / deficiency* |
| IF | 3.057 |
| 引用数 | 13 |
| WOS 分野 | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| リソース情報 | |
| ショウジョウバエ | DGRC#109793 |