RRC ID 11094
著者 Suissa Y, Kalifa Y, Dinur T, Graham P, Deshpande G, Schedl P, Gerlitz O.
タイトル Hrp48 attenuates Sxl expression to allow for proper notch expression and signaling in wing development.
ジャーナル Proc Natl Acad Sci U S A
Abstract Different signaling pathways are deployed in specific developmental contexts to generate sexually dimorphic traits. Recently, Sex-lethal (Sxl), the female determinant in Drosophila melanogaster, was shown to down-regulate Notch (N) signaling to accomplish sex-specific patterning. Paradoxically, however, both Sxl and N are ubiquitously expressed in all of the female cells. This raises a key question as to how, during monomorphic female development, N signaling escapes the negative impact of Sxl. Here, we uncover a regulatory loop involving Hrp48, an abundant Drosophila hnRNP, Sxl and N. Phenotypic consequences of the partial loss of hrp48 resemble that of N but are more pronounced in females than in males. Likewise, N levels are drastically diminished only in females. Interestingly, monomorphic female tissues including wing, eye and antennal discs display considerable increase in Sxl amounts. Finally, female-specific attenuation of N signaling is rescued upon simultaneous removal of Sxl. Thus, our data demonstrate that in monomorphic contexts, Hrp48 functions as a moderator of Sxl expression to achieve adequate levels of N receptor production and signaling. We propose that it is critical to modulate the activities of the master determinant underling sexual dimorphism, to ensure that it does not function inappropriately in monomorphic tissues and disrupt their development.
巻・号 107(15)
ページ 6930-5
公開日 2010-4-13
DOI 10.1073/pnas.0910570107
PII 0910570107
PMID 20351283
PMC PMC2872424
MeSH Alleles Animals Crosses, Genetic Drosophila Proteins / metabolism* Drosophila Proteins / physiology* Drosophila melanogaster / metabolism* Female Gene Expression Regulation, Developmental* Heterogeneous-Nuclear Ribonucleoproteins / metabolism Heterogeneous-Nuclear Ribonucleoproteins / physiology* Male Mitosis Models, Biological RNA-Binding Proteins / metabolism* Receptors, Notch / metabolism* Sex Factors Signal Transduction Wings, Animal / embryology
IF 9.412
引用数 15
WOS 分野 DEVELOPMENTAL BIOLOGY
リソース情報
ショウジョウバエ 10377R-1 18350R-3