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il2rg(del4)
| Strain information | |
|---|---|
| Strain ID | MT1584 |
| Strain Name | il2rg(del4) |
| Strain Type | Mutants |
| Symbol | del4 |
| Characteristics | With the CRISPR/Cas9 system, 4bp in exon 3 of il2rg (interleukin receptor gamma) gene have deleted. Homozygous mutants affect T cell and NK cell development. Background of this mutant is OK-cab (MT830). |
Journal
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| Special affairs [Address] |
The RECIPIENT shall refer the following publication in any PUBLICATIONS. (Name of the Publication: Sakaguchi H, Sato Y, Matsumoto R, Gomikawa J, Yoshida N, Suzuki T, Matsuda M, Iwanami N. Maturation of the medaka immune system depends on reciprocal interactions between the microbiota and the intestinal tract. Front Immunol. 2023; 14:1259519. doi: 10.3389/fimmu.2023.1259519. ) |
| Category | Mutants created by genome editing |
| Organization | National Institute for Basic Biology |
| Frozen sperm in NIBB | ○ |
| Deposited by | NIBB |
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| Image |
il2rg(del4)pic.jpg (A-D) Pictures of il2rg(del4)(strain ID: MT1584) crossed with cab-Tg(rag1-egfp)(strain ID: TG848) are shown. This MT1584 mutant itself does NOT possess rag1:egfp transgene. Developing lymphocyte-specific rag1:egfp expression in larval thymocytes at 10 days post-fertilization (dpf). Dorsal (A,C) and lateral (B,D) views of WT (A-B) and il2rg(del4) (C-D) larva. (E-F) rag1:egfp expression in adult thymocytes at two months post-fertilization (mpf). Lateral views of WT (E) and il2rg(del4) (F) fish. Note a few EGFP-positive thymocytes in il2rg mutants. |
