This mutant, isolated by TILLING screening, has a single nucleotide substitution in exon 14 of fshr (follicle stimulating hormone receptor) gene. The mutation was located in the BXXBB motif, which is involved in G protein activation and truncated the C-terminus. Homozygote female are infertile.
The RECIPIENT shall refer the following publication in any PUBLICATIONS. Murozumi N, Nakashima R, Hirai T, Kamei Y, Ishikawa-Fujiwara T, Todo T, Kitano T. Loss of follicle-stimulating hormone receptor function causes masculinization and suppression of ovarian development in genetically female medaka. Endocrinology 2014;155(8):3136-45. doi: 10.1210/en.2013-2060.
