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zmynd10
| Strain information | |
|---|---|
| Strain ID | MT1419 |
| Strain Name | zmynd10 |
| Strain Type | Mutants |
| Characteristics | zinc finger MYND-type containing 10 (zmynd10) gene was disrupted in a d-rR strain using TALEN. This mutant carries a 12-bp deletion in the 2nd exon of the zmynd10 gene. Homozygous mutants lost outer dynein arms in motile cilia that cause cilia/flagella immobility. Motility defects in cilia/flagella lead to left-right defect, sperm dysmotility, scoliosis and progressive polycystic kidney. |
| Notes |
Please note that we will use OK-Cab (MT830) for artificially insemination with frozen sperm of this strain. Homozygote is semi-viable, however, it was impossible to obtain fertilized eggs from mating between homozygotes. |
Journal
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| Special affairs [Address] |
■The RECIPIENT shall refer the following publication in any PUBLICATIONS. (Name of the Publication: KOBAYASHI, Daisuke, et al. Loss of zinc finger MYND-type containing 10 (zmynd10) affects cilia integrity and axonemal localization of dynein arms, resulting in ciliary dysmotility, polycystic kidney and scoliosis in medaka (Oryzias latipes). Developmental biology, 2017, 430.1: 69-79. ) |
| Category | Mutants created by genome editing |
| Organization | National Institute for Basic Biology |
| Frozen sperm in NIBB | ○ |
| Deposited by | Kyoto Prefectural University of Medicine |
| Order |
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| Document (PDF) | Genotyping protocol_MT1419_zmynd10 |
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