|
PEC Original Annotations
|
|
Essentiality
|
|
Class
|
non-essential
|
|
References (PMID)
|
Nucleic Acids Res. 1983;11(21):7331-45.
Nucleotide sequence of thrC and of the transcription termination region of the threonine operon in Escherichia coli K12.
Parsot C, Cossart P, Saint-Girons I, Cohen GN.
(
6316258
)
|
|
|
Deletion
|
OCR27
(D)
,
OCR27-1
(D)
,
OCR27-6
(D)
,
OCR27-7
(D)
|
|
Related gene (W3110 PEC)
|
|
Gene Search
|
Search MG1655 PEC by gene name:
thrC
|
|
Related strains
|
|
Strains Search
|
Search strains by gene name:
thrC
Search strains by all related name:
thrC b0004 ECK0004 JW0003
|
General information (Go to Linear View: )
|
|
Gene Name
|
thrC
|
|
Alternative name
|
b0004,ECK0004,JW0003
|
|
Location, Length
|
3,734 - 5,020
(
+
)
;
0.08
min
;
1287
(bp) ,
428
(aa)
|
|
Product
|
threonine synthase
|
|
Operon Name
|
thrLABC
|
|
Note
|
GO_component: GO:0005737 - cytoplasm; GO_process: GO:0009088 - threonine biosynthetic process
|
|
Function
|
enzyme; Amino acid biosynthesis: Threonine,1.5.1.8 metabolism; building block biosynthesis; amino acids; threonine,7.1 location of gene products; cytoplasm
|
|
Gene Ontology
|
GO:0003824
;
catalytic activity ( thrC )
GO:0004795
;
threonine synthase activity ( thrC )
GO:0005515
;
protein binding ( thrC )
GO:0006520
;
amino acid metabolic process ( thrC )
GO:0008152
;
metabolic process ( thrC )
GO:0008652
;
amino acid biosynthetic process ( thrC )
GO:0009088
;
threonine biosynthetic process ( thrC )
GO:0016829
;
lyase activity ( thrC )
GO:0030170
;
pyridoxal phosphate binding ( thrC )
|
|
PID
|
1786185
|
EC number
(KEGG Pathway)
|
4.2.3.1
|
|
Verified Protein Starts
(data
compiled from literature and appropriate citations are available from EcoGene)
|
|
EcoGene
|
thrC
(
EG11000
)
|
|
Number of removed
|
0 aa cleaved
|
|
SWISS-PROT
(
Show details
[
2
more]
)
|
Entry name(Acc.no)
|
THRC_ECOLI
(
P00934
)
|
|
- Protein name
|
Threonine synthase
|
|
- Synonyms
|
EC 4.2.3.1
|
|
- Gene name
|
Name=thrC; OrderedLocusNames=b0004;
|
|
Homology Analysis
|
|
BLAST
|
|
Bacteria
|
|
GTOP
|
thrC
(
homologous genes of other bacterias
)
|
|
PDB
(database updated :
2007.02.20
)
|
|
PSI-BLAST
|
Chain A, Crystal Structure Of Threonine Synthase From Escherichia Coli
|
|
SWISS-PROT
(database updated :
2007.02.20
)
|
|
BLAST
|
Threonine synthase
|
|
PSI-BLAST
|
Tryptophan synthase beta chain
|
|
nr
(database updated :
2007.02.20
)
|
|
BLAST
|
threonine synthase [Escherichia coli K12]
|
|
Pfam 28.0
(database updated :
2015-05
)
|
|
Pfam
|
|
|
PROSITE
|
|
PROSITE
|
ASN_GLYCOSYLATION
PKC_PHOSPHO_SITE
CK2_PHOSPHO_SITE
TYR_PHOSPHO_SITE
MYRISTYL
DEHYDRATASE_SER_THR
|
|
MMBR References
|
J Bacteriol. 1979;140(1):106-13.
Structural and functional analysis of cloned deoxyribonucleic acid containing the trpR-thr region of the Escherichia coli chromosome.
Gunsalus RP, Zurawski G, Yanofsky C.
(
159284
)
|
Nucleic Acids Res. 1983;11:7331-7345
Nucleotide sequence of thrC and of the termination region of the threonine operon in Escherichia coli K12.
Parsot, C., P. Cossart, I. Saint-Girons, and G. N. Cohen.
|
Nucleic Acids Res. 1981;9:339-347
Nucleotide sequence of the thrB gene of E. coli, and its two adjacent regions; the thrAB and thrBC junctions.
Cossart, P., M. Katinka, and M. Yaniv.
|
Mol Gen Genet. 1979;175(1):39-44.
Construction and expression of a hybrid plasmid containing the Escherichia coli thrA and thrB genes.
Cossart P, Katinka M, Yaniv M, Saint Girons I, Cohen GN.
(
390305
)
|
| Sequences |
Amino acid
FASTA format
|
0001 MKLYNLKDHN EQVSFAQAVT QGLGKNQGLF FPHDLPEFSL TEIDEMLKLD FVTRSAKILS AFIGDEIPQE
0071 ILEERVRAAF AFPAPVANVE SDVGCLELFH GPTLAFKDFG GRFMAQMLTH IAGDKPVTIL TATSGDTGAA
0141 VAHAFYGLPN VKVVILYPRG KISPLQEKLF CTLGGNIETV AIDGDFDACQ ALVKQAFDDE ELKVALGLNS
0211 ANSINISRLL AQICYYFEAV AQLPQETRNQ LVVSVPSGNF GDLTAGLLAK SLGLPVKRFI AATNVNDTVP
0281 RFLHDGQWSP KATQATLSNA MDVSQPNNWP RVEELFRRKI WQLKELGYAA VDDETTQQTM RELKELGYTS
0351 EPHAAVAYRA LRDQLNPGEY GLFLGTAHPA KFKESVEAIL GETLDLPKEL AERADLPLLS HNLPADFAAL
0421 RKLMMNHQ
|
Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 CGTTGCCGAC TGGTTGGGTA AGAACTACCT
-070 GCAAAATCAG GAAGGTTTTG TTCATATTTG CCGGCTGGAT ACGGCGGGCG CACGAGTACT GGAAAACTAA
0001 atgaaactct acaatctgaa agatcacaac gagcaggtca gctttgcgca agccgtaacc caggggttgg
0071 gcaaaaatca ggggctgttt tttccgcacg acctgccgga attcagcctg actgaaattg atgagatgct
0141 gaagctggat tttgtcaccc gcagtgcgaa gatcctctcg gcgtttattg gtgatgaaat cccacaggaa
0211 atcctggaag agcgcgtgcg cgcggcgttt gccttcccgg ctccggtcgc caatgttgaa agcgatgtcg
0281 gttgtctgga attgttccac gggccaacgc tggcatttaa agatttcggc ggtcgcttta tggcacaaat
0351 gctgacccat attgcgggtg ataagccagt gaccattctg accgcgacct ccggtgatac cggagcggca
0421 gtggctcatg ctttctacgg tttaccgaat gtgaaagtgg ttatcctcta tccacgaggc aaaatcagtc
0491 cactgcaaga aaaactgttc tgtacattgg gcggcaatat cgaaactgtt gccatcgacg gcgatttcga
0561 tgcctgtcag gcgctggtga agcaggcgtt tgatgatgaa gaactgaaag tggcgctagg gttaaactcg
0631 gctaactcga ttaacatcag ccgtttgctg gcgcagattt gctactactt tgaagctgtt gcgcagctgc
0701 cgcaggagac gcgcaaccag ctggttgtct cggtgccaag cggaaacttc ggcgatttga cggcgggtct
0771 gctggcgaag tcactcggtc tgccggtgaa acgttttatt gctgcgacca acgtgaacga taccgtgcca
0841 cgtttcctgc acgacggtca gtggtcaccc aaagcgactc aggcgacgtt atccaacgcg atggacgtga
0911 gtcagccgaa caactggccg cgtgtggaag agttgttccg ccgcaaaatc tggcaactga aagagctggg
0981 ttatgcagcc gtggatgatg aaaccacgca acagacaatg cgtgagttaa aagaactggg ctacacttcg
1051 gagccgcacg ctgccgtagc ttatcgtgcg ctgcgtgatc agttgaatcc aggcgaatat ggcttgttcc
1121 tcggcaccgc gcatccggcg aaatttaaag agagcgtgga agcgattctc ggtgaaacgt tggatctgcc
1191 aaaagagctg gcagaacgtg ctgatttacc cttgctttca cataatctgc ccgccgattt tgctgcgttg
1261 cgtaaattga tgatgaatca tcagtaaAAT CTATTCATTA TCTCAATCAG GCCGGGTTTG CTTTTATGCA
1331 GCCCGGCTTT TTTATGAAGA AATTATGGAG AAAAATGACA GGGAAAAAGG AGAAATT
|
