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PEC Original Annotations
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Essentiality
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Class
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essential
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References (PMID)
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EMBO J. 1990;9(10):3209-16.
The secD locus of E.coli codes for two membrane proteins required for protein export.
Gardel C, Johnson K, Jacq A, Beckwith J.
(
2170107
)
|
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Deletion
|
OCR39
(D)
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Related gene (W3110 PEC)
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Gene Search
|
Search MG1655 PEC by gene name:
secD
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Related strains
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Strains Search
|
Search strains by gene name:
secD
Search strains by all related name:
secD b0408 ECK0402 JW0398
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General information (Go to Linear View: )
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Gene Name
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secD
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Alternative name
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b0408,ECK0402,JW0398
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Location, Length
|
426,871 - 428,718
(
+
)
;
9.20
min
;
1848
(bp) ,
615
(aa)
|
|
Product
|
SecYEG protein translocase auxillary subunit
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Operon Name
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tgt-yajC-secDF
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Note
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protein secretion; membrane protein, part of the channel; GO_component: GO:0009274 - peptidoglycan-based cell wall; GO_component: GO:0019866 - organelle inner membrane
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Function
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transport; Protein, peptide secretion
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Gene Ontology
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GO:0005886
;
plasma membrane ( secD )
GO:0006810
;
transport ( secD )
GO:0006886
;
intracellular protein transport ( secD )
GO:0008565
;
protein transporter activity ( secD )
GO:0009276
;
1-2nm peptidoglycan-based cell wall ( secD )
GO:0015031
;
protein transport ( secD )
GO:0015450
;
P-P-bond-hydrolysis-driven protein transmembrane transporter activity ( secD )
GO:0015627
;
type II protein secretion system complex ( secD )
GO:0015628
;
protein secretion by the type II secretion system ( secD )
GO:0016020
;
membrane ( secD )
GO:0016021
;
integral to membrane ( secD )
GO:0065002
;
intracellular protein transport across a membrane ( secD )
|
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PID
|
1786609
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EC number
(KEGG Pathway)
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SWISS-PROT
(
Show details
[
1
more]
)
|
Entry name(Acc.no)
|
SECD_ECOLI
(
P19673
;
P72348; P77531
)
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- Protein name
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Protein-export membrane protein secD.
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- Synonyms
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- Gene name
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Name=secD; OrderedLocusNames=b0408, z0507, ECs0459, SF0345, S0353;
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Homology Analysis
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BLAST
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Bacteria
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GTOP
|
secD
(
homologous genes of other bacterias
)
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PDB
(database updated :
2007.02.20
)
|
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PSI-BLAST
|
Chain A, Coiled-Coil Domain Of Dmpk
|
|
SWISS-PROT
(database updated :
2007.02.20
)
|
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BLAST
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Protein-export membrane protein secD
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PSI-BLAST
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Protein-export membrane protein secD
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nr
(database updated :
2007.02.20
)
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BLAST
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protein export protein SecD [Escherichia coli O157:H7 EDL933]
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Pfam 28.0
(database updated :
2015-05
)
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Pfam
|
|
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PROSITE
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|
PROSITE
|
ASN_GLYCOSYLATION
CAMP_PHOSPHO_SITE
PKC_PHOSPHO_SITE
CK2_PHOSPHO_SITE
TYR_PHOSPHO_SITE
MYRISTYL
AMIDATION
SPASE_I_3
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MMBR References
|
J Bacteriol. 1987;169(3):1286-90.
secD, a new gene involved in protein export in Escherichia coli.
Gardel C, Benson S, Hunt J, Michaelis S, Beckwith J.
(
3029032
)
|
J Bacteriol. 1993;175:6113-6117
Processing of lipid-modified prolipoprotein requires energy and sec gene products in vivo.
Kosic, N., M. Sugai, C. K. Fan, and H. C. Wu.
|
J Bacteriol. 1992;174(5):1709-10.
Alignment of genes from the 9-minute region (araJ to tsx) of the Escherichia coli K-12 linkage map to the physical map.
Lucht JM, Boos W, Bremer E.
(
1537816
)
|
J Bacteriol. 1994;176:804-814
Genetic and molecular characterization of the Escherichia coli secD operon and its products.
Pogliano, K. J., and J. R. Beckwith.
|
J Bacteriol. 1995;177:4969-4973
Multicopy suppression of cold-sensitive sec mutations in Escherichia coli.
Danese, P. N., C. K. Murphy, and T. J. Silhavy.
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| Sequences |
Amino acid
FASTA format
|
0001 MLNRYPLWKY VMLIVVIVIG LLYALPNLFG EDPAVQITGA RGVAASEQTL IQVQKTLQEE KITAKSVALE
0071 EGAILARFDS TDTQLRAREA LMGVMGDKYV VALNLAPATP RWLAAIHAEP MKLGLDLRGG VHFLMEVDMD
0141 TALGKLQEQN IDSLRSDLRE KGIPYTTVRK ENNYGLSITF RDAKARDEAI AYLSKRHPDL VISSQGSNQL
0211 RAVMSDARLS EAREYAVQQN INILRNRVNQ LGVAEPVVQR QGADRIVVEL PGIQDTARAK EILGATATLE
0281 FRLVNTNVDQ AAAASGRVPG DSEVKQTREG QPVVLYKRVI LTGDHITDST SSQDEYNQPQ VNISLDSAGG
0351 NIMSNFTKDN IGKPMATLFV EYKDSGKKDA NGRAVLVKQE EVINIANIQS RLGNSFRITG INNPNEARQL
0421 SLLLRAGALI APIQIVEERT IGPTLGMQNI EQGLEACLAG LLVSILFMII FYKKFGLIAT SALIANLILI
0491 VGIMSLLPGA TLSMPGIAGI VLTLAVAVDA NVLINERIKE ELSNGRTVQQ AIDEGYRGAF SSIFDANITT
0561 LIKVIILYAV GTGAIKGFAI TTGIGVATSM FTAIVGTRAI VNLLYGGKRV KKLSI
|
Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 CACCACTGAA GTAGTTATTA AACGTGACTT
-070 CGTAGCTGCC GTCCTGCCGA AAGGCACCAT GAAGGCGCTG TAATTAAAAT TTTTCCCTAA GGGAATTGCC
0001 gtgttaaacc gttatccttt gtggaagtac gtcatgctga tcgtggtgat tgtcatcggt ctgctgtatg
0071 cgcttcccaa cctgtttggt gaggatccgg ctgttcagat cactggtgcg cgcggagtcg ccgccagtga
0141 gcaaacgctg atccaggtcc agaaaacgtt acaagaagaa aaaataactg ctaagtctgt ggcactggaa
0211 gagggcgcta ttcttgcgcg cttcgactcc actgacaccc agttgcgcgc tcgtgaagca ttaatgggcg
0281 ttatgggtga caaatacgtc gtggcgctta accttgcccc ggcaacgccg cgctggctgg cagctattca
0351 cgctgagccg atgaagctcg gccttgacct gcgtggcggc gttcacttcc tgatggaagt ggatatggac
0421 accgcgcttg gcaaactcca ggaacaaaat atcgatagcc tacgcagtga cctgcgcgaa aagggcatcc
0491 cgtataccac tgttcgtaaa gaaaacaact acggcctgag catcactttc cgcgatgcta aagctcgtga
0561 tgaagccatt gcgtatctga gcaagcgcca tccggacctg gtgattagca gccagggcag caaccagctg
0631 cgtgcggtaa tgagcgatgc tcgtctgagt gaagcgcgtg aatatgcggt gcagcagaac attaatatcc
0701 tgcgtaaccg tgtaaaccaa cttggcgtgg cggagccggt ggttcagcgt cagggtgctg accgtatcgt
0771 tgttgaactg ccaggtattc aggacactgc gcgtgcgaaa gagattctgg gtgcgacggc aacgctggaa
0841 ttccgtctgg taaacaccaa cgttgaccag gccgctgcgg catccggtcg cgtaccgggc gactctgaag
0911 tgaaacagac ccgcgaaggt cagccagttg tgctgtacaa acgcgtaatt ctgaccggtg accatatcac
0981 cgactccact tccagccagg acgaatacaa ccaaccgcag gttaacatct cgctcgatag cgctggtggt
1051 aacatcatgt ctaacttcac taaggacaac atcggcaaac cgatggcaac cctgtttgtg gagtacaaag
1121 acagcggtaa gaaagatgca aatggtcgtg cggttctggt gaaacaggaa gaggtgatta acatcgccaa
1191 catccagtct cgtctgggta acagcttccg tatcaccggc atcaacaacc cgaacgaagc ccgtcagctg
1261 tcactgctgc tgcgtgccgg tgcgttgatc gcgccgattc agattgttga agaacgtacc attggcccaa
1331 ccctgggtat gcagaacatt gaacaggggc tggaggcttg ccttgccggt ctgctggttt ctattctgtt
1401 catgatcatc ttctataaga agtttggtct gattgcgacc agtgctctga ttgccaactt gatcttaatc
1471 gtcggcatta tgtcgctgtt gccaggcgca acgctgagta tgccaggtat cgcgggtatc gtcttaaccc
1541 ttgcggtggc ggtcgatgcg aacgtactga tcaacgaacg tattaaagaa gagttgagca acggacgtac
1611 tgttcaacag gcaattgatg aaggttatcg tggcgcattc agttctatct tcgatgcgaa catcaccacg
1681 ctgattaaag tcatcatcct gtacgcagtg ggtaccgggg caattaaagg gttcgcgatt actaccggta
1751 tcggtgtggc gacgtcgatg tttaccgcga ttgtcggtac gcgtgccatc gtaaacctgc tatatggcgg
1821 caagcgcgtc aagaagctgt caatctgaGG AGTGCGATGT GGCACAGGAA TATACTGTTG AACAACTAAA
1891 CCACGGCCGT AAAGTCTATG ACTTTATGCG CTGGGACTAC TGGGCTTTCG GCATCTCT
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