|
PEC Original Annotations
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|
Essentiality
|
|
Class
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non-essential
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|
References (PMID)
|
Escherichia coli and Salmonella, Cellular and Molecular Biology Second Edition. ASM Press. 1996
Neidhart, F.C.
|
|
|
Deletion
|
OCR29
(D)
|
|
Related gene (W3110 PEC)
|
|
Gene Search
|
Search MG1655 PEC by gene name:
pdxA
|
|
Related strains
|
|
Strains Search
|
Search strains by gene name:
pdxA
Search strains by all related name:
pdxA b0052 ECK0053 JW0051
|
General information (Go to Linear View: )
|
|
Gene Name
|
pdxA
|
|
Alternative name
|
b0052,ECK0053,JW0051
|
|
Location, Length
|
52,427 - 53,416
(
-
)
;
1.13
min
;
990
(bp) ,
329
(aa)
|
|
Product
|
4-hydroxy-L-threonine phosphate dehydrogenase, NAD-dependent
|
|
Operon Name
|
lptD-surA-pdxA-rsmA-apaGH
|
|
Note
|
pyridoxine biosynthesis; GO_component: GO:0005737 - cytoplasm; GO_process: GO:0008615 - pyridoxine biosynthetic process
|
|
Function
|
enzyme; Biosynthesis of cofactors, carriers: Pyridoxine
|
|
Gene Ontology
|
GO:0000287
;
magnesium ion binding ( pdxA )
GO:0005737
;
cytoplasm ( pdxA )
GO:0008270
;
zinc ion binding ( pdxA )
GO:0008615
;
pyridoxine biosynthetic process ( pdxA )
GO:0016491
;
oxidoreductase activity ( pdxA )
GO:0042823
;
pyridoxal phosphate biosynthetic process ( pdxA )
GO:0046872
;
metal ion binding ( pdxA )
GO:0050570
;
4-hydroxythreonine-4-phosphate dehydrogenase activity ( pdxA )
GO:0050897
;
cobalt ion binding ( pdxA )
GO:0051287
;
NAD binding ( pdxA )
|
|
PID
|
1786237
|
EC number
(KEGG Pathway)
|
1.1.1.262
|
|
SWISS-PROT
(
Show details
[
2
more]
)
|
Entry name(Acc.no)
|
PDXA_ECOLI
(
P19624
)
|
|
- Protein name
|
4-hydroxythreonine-4-phosphate dehydrogenase
|
|
- Synonyms
|
EC 1.1.1.262, 4- (phosphohydroxy)-L-threonine dehydrogenase
|
|
- Gene name
|
Name=pdxA; OrderedLocusNames=b0052;
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Homology Analysis
|
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BLAST
|
|
Bacteria
|
|
GTOP
|
pdxA
(
homologous genes of other bacterias
)
|
|
PDB
(database updated :
2007.02.20
)
|
|
PSI-BLAST
|
Chain A, Crystal Structure Of E.Coli Pdxa
|
|
SWISS-PROT
(database updated :
2007.02.20
)
|
|
BLAST
|
4-hydroxythreonine-4-phosphate dehydrogenase
|
|
PSI-BLAST
|
4-hydroxythreonine-4-phosphate dehydrogenase
|
|
nr
(database updated :
2007.02.20
)
|
|
BLAST
|
4-hydroxythreonine-4-phosphate dehydrogenase [Escherichia coli K12]
|
|
Pfam 28.0
(database updated :
2015-05
)
|
|
Pfam
|
|
|
PROSITE
|
|
PROSITE
|
ASN_GLYCOSYLATION
PKC_PHOSPHO_SITE
CK2_PHOSPHO_SITE
MYRISTYL
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|
MMBR References
|
J Bacteriol. 1971;107(2):580-2.
Identification of the forms of vitamin B 6 present in the culture media of "vitamin B 6 control" mutants.
Dempsey WB, Arcement LJ.
(
4939769
)
|
Mol Gen Genet. 1980;179(1):211-6.
Genetic organization and restriction enzyme cleavage map of the ksgA-pdxA region of the Escherichia coli chromosome.
Andresson OS, Davies JE.
(
6256606
)
|
Mol Gen Genet. 1980;179(1):201-9.
Isolation and characterization of lambda transducing phages for the E. coli genes ksgA and pdxA.
Andresson OS, Davies JE.
(
6450312
)
|
| Sequences |
Amino acid
FASTA format
|
0001 MVKTQRVVIT PGEPAGIGPD LVVQLAQREW PVELVVCADA TLLTNRAAML GLPLTLRPYS PNSPAQPQTA
0071 GTLTLLPVAL RAPVTAGQLA VENGHYVVET LARACDGCLN GEFAALITGP VHKGVINDAG IPFTGHTEFF
0141 EERSQAKKVV MMLATEELRV ALATTHLPLR DIADAITPAL LHEVIAILHH DLRTKFGIAE PRILVCGLNP
0211 HAGEGGHMGT EEIDTIIPVL NELRAQGMKL NGPLPADTLF QPKYLDNADA VLAMYHDQGL PVLKYQGFGR
0281 GVNITLGLPF IRTSVDHGTA LELAGRGKAD VGSFITALNL AIKMIVNTQ
|
Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 gtgcataccg catgctgatg aaccgtaagt
-070 tctcggaaga agcagcaagc tggatgcagg aacaacgtgc cagcgcctac gttaaaatcc tgagcaacta
0001 atggttaaaa cccaacgtgt tgtgatcact cccggcgagc ccgccgggat tggcccggac ttagttgtcc
0071 agcttgcaca gcgtgagtgg ccggtcgaac tggttgtttg tgccgatgcc actctcctta ccaaccgggc
0141 agcgatgctc ggtttgccgc tcaccctccg cccttattcc cccaactccc ctgcacaacc gcaaactgcg
0211 ggcacattaa cgctacttcc tgtcgcgcta cgtgcacctg tcactgcggg gcagttagcg gttgaaaatg
0281 ggcattatgt ggtggaaacg ctggcgcgag cgtgcgatgg ttgtctgaac ggcgaatttg ccgcgctgat
0351 cacaggtccg gtgcataaag gcgttattaa cgacgctggc attcctttta ccggtcatac cgagtttttc
0421 gaagagcgtt cgcaggcgaa aaaggtggtg atgatgctgg cgaccgaaga acttcgcgtg gcgctggcaa
0491 cgacgcattt accgctgcgc gatatcgcag acgctatcac ccctgcactt ttgcacgaag tgattgctat
0561 tttgcatcac gatttgcgga ccaaatttgg tattgccgaa ccgcgcattc tggtctgcgg gctgaatccg
0631 cacgcgggcg aaggcggtca tatgggtacg gaagagatag acaccattat tccggtgctc aatgagctgc
0701 gggcgcaggg gatgaaactc aacgggccgc tgcctgccga taccctgttt cagccgaaat atcttgataa
0771 cgccgacgcc gtgctggcga tgtaccacga tcagggtctt cccgtgctaa aataccaggg cttcgggcgc
0841 ggtgtgaaca ttacgctggg cctgcccttt attcgcacat cagtggacca cggcaccgcg cttgaactgg
0911 cgggacgtgg caaagccgat gtcggcagtt ttattacggc gcttaatctc gccatcaaaa tgattgttaa
0981 cacccaatga ataatcgagt ccaccagggc cacttagccc gtaaacgctt cgggcaaaac tttctcaacg
1051 atcagttcgt gatcgacagt attgtgtctg ccattaaccc
|
