|
PEC Original Annotations
|
|
Essentiality
|
|
Class
|
non-essential
|
|
References (PMID)
|
Escherichia coli and Salmonella, Cellular and Molecular Biology Second Edition. ASM Press. 1996
Neidhart, F.C.
|
|
|
Deletion
|
ppdel-6
(LD)
,
OCR32
(D)
|
|
Related gene (W3110 PEC)
|
|
Gene Search
|
Search MG1655 PEC by gene name:
panC
|
|
Related strains
|
|
Strains Search
|
Search strains by gene name:
panC
Search strains by all related name:
panC b0133 ECK0132 JW0129
|
General information (Go to Linear View: )
|
|
Gene Name
|
panC
|
|
Alternative name
|
b0133,ECK0132,JW0129
|
|
Location, Length
|
147,944 - 148,795
(
-
)
;
3.19
min
;
852
(bp) ,
283
(aa)
|
|
Product
|
pantothenate synthetase
|
|
Operon Name
|
panBC
|
|
Note
|
GO_component: GO:0005737 - cytoplasm; GO_process: GO:0015937 - coenzyme A biosynthetic process
|
|
Function
|
enzyme; Biosynthesis of cofactors, carriers: Pantothenate
|
|
Gene Ontology
|
GO:0000166
;
nucleotide binding ( panC )
GO:0003824
;
catalytic activity ( panC )
GO:0004592
;
pantoate-beta-alanine ligase activity ( panC )
GO:0005515
;
protein binding ( panC )
GO:0005524
;
ATP binding ( panC )
GO:0005737
;
cytoplasm ( panC )
GO:0009058
;
biosynthetic process ( panC )
GO:0015940
;
pantothenate biosynthetic process ( panC )
GO:0016874
;
ligase activity ( panC )
|
|
PID
|
1786325
|
EC number
(KEGG Pathway)
|
6.3.2.1
|
|
SWISS-PROT
(
Show details
[
2
more]
)
|
Entry name(Acc.no)
|
PANC_ECOLI
(
P31663
)
|
|
- Protein name
|
Pantoate--beta-alanine ligase
|
|
- Synonyms
|
EC 6.3.2.1, Pantothenate synthetase, Pantoate activating enzyme
|
|
- Gene name
|
Name=panC; OrderedLocusNames=b0133;
|
|
Homology Analysis
|
|
BLAST
|
|
Bacteria
|
|
GTOP
|
panC
(
homologous genes of other bacterias
)
|
|
PDB
(database updated :
2007.02.20
)
|
|
PSI-BLAST
|
Chain A, Crystal Apo-Structure Of Pantothenate Synthetase From E. Coli
|
|
SWISS-PROT
(database updated :
2007.02.20
)
|
|
BLAST
|
Pantoate--beta-alanine ligase
|
|
PSI-BLAST
|
Pantoate--beta-alanine ligase
|
|
nr
(database updated :
2007.02.20
)
|
|
BLAST
|
pantoate--beta-alanine ligase [Escherichia coli K12]
|
|
Pfam 28.0
(database updated :
2015-05
)
|
|
Pfam
|
|
|
PROSITE
|
|
PROSITE
|
ASN_GLYCOSYLATION
PKC_PHOSPHO_SITE
CK2_PHOSPHO_SITE
TYR_PHOSPHO_SITE
MYRISTYL
AMIDATION
LEUCINE_ZIPPER
|
|
MMBR References
|
FEMS Microbiol Lett. 1996;143(2-3):247-52.
Characterization and sequence of the Escherichia coli panBCD gene cluster.
Merkel WK, Nichols BP.
(
8837478
)
|
J Bacteriol. 1982;149(3):916-22.
Genetic and biochemical analyses of pantothenate biosynthesis in Escherichia coli and Salmonella typhimurium.
Cronan JE Jr, Littel KJ, Jackowski S.
(
7037743
)
|
| Sequences |
Amino acid
FASTA format
|
0001 MLIIETLPLL RQQIRRLRME GKRVALVPTM GNLHDGHMKL VDEAKARADV VVVSIFVNPM QFDRPEDLAR
0071 YPRTLQEDCE KLNKRKVDLV FAPSVKEIYP NGTETHTYVD VPGLSTMLEG ASRPGHFRGV STIVSKLFNL
0141 VQPDIACFGE KDFQQLALIR KMVADMGFDI EIVGVPIMRA KDGLALSSRN GYLTAEQRKI APGLYKVLSS
0211 IADKLQAGER DLDEIITIAG QELNEKGFRA DDIQIRDADT LLEVSETSKR AVILVAAWLG DARLIDNKMV
0281 ELA
|
Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 aaacgggcga catccgcgcg gctgtgcggc
-070 agtatatggc tgaagtggag tccggcgttt atccgggcga agaacacagt ttccattaag gagtcacgtt
0001 gtgttaatta tcgaaaccct gccgctgctg cgtcagcaaa ttcgccgcct gcgtatggaa ggcaagcgcg
0071 tggcgctggt gcctaccatg ggtaacctgc acgatggcca tatgaagctg gtcgacgaag ccaaagcccg
0141 cgccgatgtg gtcgtcgtca gtattttcgt taacccgatg cagttcgacc gcccggaaga tctggctcgt
0211 tatccacgga ccttgcagga ggactgcgag aagctaaaca aacgtaaagt ggatttagtt ttcgcccctt
0281 cggtaaaaga gatctacccg aacggtactg aaacccacac ttacgttgac gttcctggcc tttcgaccat
0351 gctggaaggt gccagccgtc cgggacattt tcgcggcgtt tcgactattg tcagcaagct gttcaacctg
0421 gtccagccgg acatcgcctg cttcggtgaa aaagattttc agcaactggc gctgatccgc aaaatggttg
0491 ccgatatggg cttcgatatt gagattgtcg gtgtgccaat tatgcgcgcc aaagacggtc tggcgctaag
0561 ttcccgtaac ggttatctga cggcggaaca acgcaaaatt gcgcctggtc tgtacaaagt tttaagttcg
0631 attgctgaca aattgcaggc tggggaacgg gatctcgatg aaattattac cattgcgggg caagaactga
0701 atgaaaaagg cttccgcgcc gatgatattc agattcgcga tgccgacaca ttgctggaag tttctgaaac
0771 cagcaaacgg gcagtaattc tggtagccgc ctggcttggc gatgctcgcc tgatcgacaa caaaatggtc
0841 gagctggcgt aatacttaac tggcgctacg gctgatggcg ccagttatta atttacccca cgtcatctgt
0911 cataacacag gtaacttaaa taaggttaat taccttatca at
|
