|
PEC Original Annotations
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|
Essentiality
|
|
Class
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non-essential
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|
References (PMID)
|
Escherichia coli and Salmonella, Cellular and Molecular Biology Second Edition. ASM Press. 1996
Neidhart, F.C.
|
|
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Deletion
|
ppdel-6
(LD)
,
OCR32
(D)
|
|
Related gene (W3110 PEC)
|
|
Gene Search
|
Search MG1655 PEC by gene name:
panB
|
|
Related strains
|
|
Strains Search
|
Search strains by gene name:
panB
Search strains by all related name:
panB b0134 ECK0133 JW0130 panA
|
General information (Go to Linear View: )
|
|
Gene Name
|
panB
|
|
Alternative name
|
b0134,ECK0133,JW0130,panA
|
|
Location, Length
|
148,807 - 149,601
(
-
)
;
3.21
min
;
795
(bp) ,
264
(aa)
|
|
Product
|
3-methyl-2-oxobutanoate hydroxymethyltransferase
|
|
Operon Name
|
panBC
|
|
Note
|
GO_component: GO:0005737 - cytoplasm; GO_process: GO:0015937 - coenzyme A biosynthetic process
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Function
|
enzyme; Biosynthesis of cofactors, carriers: Pantothenate
|
|
Gene Ontology
|
GO:0000287
;
magnesium ion binding ( panB )
GO:0003824
;
catalytic activity ( panB )
GO:0003864
;
3-methyl-2-oxobutanoate hydroxymethyltransferase activity ( panB )
GO:0005624
;
membrane fraction ( panB )
GO:0005737
;
cytoplasm ( panB )
GO:0008168
;
methyltransferase activity ( panB )
GO:0015940
;
pantothenate biosynthetic process ( panB )
GO:0016740
;
transferase activity ( panB )
GO:0046872
;
metal ion binding ( panB )
|
|
PID
|
1786326
|
EC number
(KEGG Pathway)
|
2.1.2.11
|
|
Verified Protein Starts
(data
compiled from literature and appropriate citations are available from EcoGene)
|
|
EcoGene
|
panB
(
EG11675
)
|
|
Number of removed
|
0 aa cleaved
|
|
SWISS-PROT
(
Show details
[
2
more]
)
|
Entry name(Acc.no)
|
PANB_ECOLI
(
P31057
)
|
|
- Protein name
|
3-methyl-2-oxobutanoate hydroxymethyltransferase
|
|
- Synonyms
|
EC 2.1.2.11, Ketopantoate hydroxymethyltransferase
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- Gene name
|
Name=panB; OrderedLocusNames=b0134;
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MMBR References
|
J Bacteriol. 1993;175:2125-2130
Cloning and sequencing of the Escherichia coli panB gene, which encodes ketopantoate hydroxymethyltransferase, and overexpression of the enzyme.
Jones, C. E., J. M. Brook, D. Buck, C. Abell, and A. G. Smith.
|
FEMS Microbiol Lett. 1996;143(2-3):247-52.
Characterization and sequence of the Escherichia coli panBCD gene cluster.
Merkel WK, Nichols BP.
(
8837478
)
|
J Bacteriol. 1982;149(3):916-22.
Genetic and biochemical analyses of pantothenate biosynthesis in Escherichia coli and Salmonella typhimurium.
Cronan JE Jr, Littel KJ, Jackowski S.
(
7037743
)
|
| Sequences |
Amino acid
FASTA format
|
0001 MKPTTISLLQ KYKQEKKRFA TITAYDYSFA KLFADEGLNV MLVGDSLGMT VQGHDSTLPV TVADIAYHTA
0071 AVRRGAPNCL LLADLPFMAY ATPEQAFENA ATVMRAGANM VKIEGGEWLV ETVQMLTERA VPVCGHLGLT
0141 PQSVNIFGGY KVQGRGDEAG DQLLSDALAL EAAGAQLLVL ECVPVELAKR ITEALAIPVI GIGAGNVTDG
0211 QILVMHDAFG ITGGHIPKFA KNFLAETGDI RAAVRQYMAE VESGVYPGEE HSFH
|
Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 ctgtcacctt ctggcagtgc tgctacggat
-070 aaatcattgc ccccaccaat gtgactgata aaatgccaga cagcacaaca tcaatttatc aggatacgtt
0001 atgaaaccga ccaccatctc cttactgcag aagtacaaac aggaaaaaaa acgtttcgcg accatcaccg
0071 cttatgacta tagcttcgcc aaactctttg ctgatgaagg gcttaacgtc atgctggtgg gcgattcgct
0141 gggcatgacg gttcaggggc acgactccac cctgccagtt accgttgccg atatcgccta ccacactgcc
0211 gccgtacgtc gcggcgcacc aaactgcctg ctgctggctg acctgccgtt tatggcgtat gccacgccgg
0281 aacaagcctt cgaaaacgcc gcaacggtta tgcgtgccgg tgctaacatg gtcaaaattg aaggcggtga
0351 gtggctggta gaaaccgtac aaatgctgac cgaacgtgcc gttcctgtat gtggtcactt aggtttaaca
0421 ccacagtcag tgaatatttt cggtggctac aaagttcagg ggcgcggcga tgaagcgggc gatcaactgc
0491 tcagcgatgc attagcctta gaagctgctg gggcacagct gctggtgctg gaatgcgtgc cggttgaact
0561 ggcaaaacgt attaccgaag cactggcgat cccggttatt ggcattggcg caggcaacgt cactgacggg
0631 cagatcctcg tgatgcacga cgcctttggt attaccggcg gtcacattcc taaattcgct aaaaatttcc
0701 tcgccgaaac gggcgacatc cgcgcggctg tgcggcagta tatggctgaa gtggagtccg gcgtttatcc
0771 gggcgaagaa cacagtttcc attaaggagt cacgttgtgt taattatcga aaccctgccg ctgctgcgtc
0841 agcaaattcg ccgcctgcgt atggaaggca agcgcgtggc gctggtgcct accat
|
