PEC Original Annotations
|
Essentiality
|
Class
|
non-essential
|
References (PMID)
|
Escherichia coli and Salmonella, Cellular and Molecular Biology Second Edition. ASM Press. 1996
Neidhart, F.C.
|
|
Deletion
|
OCR30
(D)
|
Related gene (W3110 PEC)
|
Gene Search
|
Search MG1655 PEC by gene name:
leuC
|
Related strains
|
Strains Search
|
Search strains by gene name:
leuC
Search strains by all related name:
leuC b0072 ECK0074 JW0071
|
General information (Go to Linear View:)
|
Gene Name
|
leuC
|
Alternative name
|
b0072,ECK0074,JW0071
|
Location, Length
|
79,464 - 80,864
(
-
)
;
1.71
min
;
1401
(bp) ,
466
(aa)
|
Product
|
3-isopropylmalate dehydratase large subunit
|
Operon Name
|
leuLABCD
|
Note
|
3-isopropylmalate isomerase (dehydratase) subunit; GO_component: GO:0005737 - cytoplasm; GO_process: GO:0009098 - leucine biosynthetic process
|
Function
|
enzyme; Amino acid biosynthesis: Leucine
|
Gene Ontology
|
GO:0003861
;
3-isopropylmalate dehydratase activity ( leuC )
GO:0005506
;
iron ion binding ( leuC )
GO:0008152
;
metabolic process ( leuC )
GO:0008652
;
amino acid biosynthetic process ( leuC )
GO:0009082
;
branched chain family amino acid biosynthetic process ( leuC )
GO:0009098
;
leucine biosynthetic process ( leuC )
GO:0016829
;
lyase activity ( leuC )
GO:0016836
;
hydro-lyase activity ( leuC )
GO:0046872
;
metal ion binding ( leuC )
GO:0051536
;
iron-sulfur cluster binding ( leuC )
GO:0051539
;
4 iron, 4 sulfur cluster binding ( leuC )
|
PID
|
1786259
|
EC number
(KEGG Pathway)
|
4.2.1.33
|
Verified Protein Starts
(data
compiled from literature and appropriate citations are available from EcoGene)
|
EcoGene
|
leuC
(
EG11576
)
|
Number of removed
|
1 aa cleaved
|
SWISS-PROT
(
Show details
[
1
more]
)
|
Entry name(Acc.no)
|
LEU2_ECOLI
(
P30127
;
P78042; Q8FL77
)
|
- Protein name
|
3-isopropylmalate dehydratase large subunit
|
- Synonyms
|
EC 4.2.1.33, Isopropylmalate isomerase, Alpha-IPM isomerase, IPMI
|
- Gene name
|
Name=leuC; OrderedLocusNames=b0072, c0089;
|
MMBR References
|
J Bacteriol. 1977;129(2):1078-90.
Isolation and characterization of lambda pleu bacteriophages.
Davis MG, Calvo JM.
(
320178
)
|
Sequences |
Amino acid
FASTA format
|
0001 MAKTLYEKLF DAHVVYEAEN ETPLLYIDRH LVHEVTSPQA FDGLRAHGRP VRQPGKTFAT MDHNVSTQTK
0071 DINACGEMAR IQMQELIKNC KEFGVELYDL NHPYQGIVHV MGPEQGVTLP GMTIVCGDSH TATHGAFGAL
0141 AFGIGTSEVE HVLATQTLKQ GRAKTMKIEV QGKAAPGITA KDIVLAIIGK TGSAGGTGHV VEFCGEAIRD
0211 LSMEGRMTLC NMAIEMGAKA GLVAPDETTF NYVKGRLHAP KGKDFDDAVA YWKTLQTDEG ATFDTVVTLQ
0281 AEEISPQVTW GTNPGQVISV NDNIPDPASF ADPVERASAE KALAYMGLKP GIPLTEVAID KVFIGSCTNS
0351 RIEDLRAAAE IAKGRKVAPG VQALVVPGSG PVKAQAEAEG LDKIFIEAGF EWRLPGCSMC LAMNNDRLNP
0421 GERCASTSNR NFEGRQGRGG RTHLVSPAMA AAAAVTGHFA DIRNIK
|
Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 aaggcattcg caccggggat ttagcccgtg
-070 gcgctgccgc cgttagtacc gatgaaatgg gcgatatcat tgcccgctat gtagcagaag gggtgtaatc
0001 atggctaaga cgttatacga aaaattgttc gacgctcacg ttgtgtacga agccgaaaac gaaaccccac
0071 tgttatatat cgaccgccac ctggtgcatg aagtgacctc accgcaggcg ttcgatggtc tgcgcgccca
0141 cggtcgcccg gtacgtcagc cgggcaaaac cttcgctacc atggatcaca acgtctctac ccagaccaaa
0211 gacattaatg cctgcggtga aatggcgcgt atccagatgc aggaactgat caaaaactgc aaagaatttg
0281 gcgtcgaact gtatgacctg aatcacccgt atcaggggat cgtccacgta atggggccgg aacagggcgt
0351 caccttgccg gggatgacca ttgtctgcgg cgactcgcat accgccaccc acggcgcgtt tggcgcactg
0421 gcctttggta tcggcacttc cgaagttgaa cacgtactgg caacgcaaac cctgaaacag ggccgcgcaa
0491 aaaccatgaa aattgaagtc cagggcaaag ccgcgccggg cattaccgca aaagatatcg tgctggcaat
0561 tatcggtaaa accggtagcg caggcggcac cgggcatgtg gtggagtttt gcggcgaagc aatccgtgat
0631 ttaagcatgg aaggtcgtat gaccctgtgc aatatggcaa tcgaaatggg cgcaaaagcc ggtctggttg
0701 caccggacga aaccaccttt aactatgtca aaggccgtct gcatgcgccg aaaggcaaag atttcgacga
0771 cgccgttgcc tactggaaaa ccctgcaaac cgacgaaggc gcaactttcg ataccgttgt cactctgcaa
0841 gcagaagaaa tttcaccgca ggtcacctgg ggcaccaatc ccggccaggt gatttccgtg aacgacaata
0911 ttcccgatcc ggcttcgttt gccgatccgg ttgaacgcgc gtcggcagaa aaagcgctgg cctatatggg
0981 gctgaaaccg ggtattccgc tgaccgaagt ggctatcgac aaagtgttta tcggttcctg taccaactcg
1051 cgcattgaag atttacgcgc ggcagcggag atcgccaaag ggcgaaaagt cgcgccaggc gtgcaggcac
1121 tggtggttcc cggctctggc ccggtaaaag cccaggcgga agcggaaggt ctggataaaa tctttattga
1191 agccggtttt gaatggcgct tgcctggctg ctcaatgtgt ctggcgatga acaacgaccg tctgaatccg
1261 ggcgaacgtt gtgcctccac cagcaaccgt aactttgaag gccgccaggg gcgcggcggg cgcacgcatc
1331 tggtcagccc ggcaatggct gccgctgctg ctgtgaccgg acatttcgcc gacattcgca acattaaata
1401 aggagcacac catggcagag aaatttatca aacacacagg cctggtggtt ccgctggatg ccgccaatgt
1471 cgataccgat gcaatcatcc cgaaacagtt t
|