MG1655
W3110
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Gene Report : guaC
PEC Original Annotations
Essentiality
     Class non-essential
     References (PMID)
Escherichia coli and Salmonella, Cellular and Molecular Biology Second Edition. ASM Press. 1996
Neidhart, F.C.
     Deletion OCR31 (D)  ,  OCR31-7 (D)  
Related gene (W3110 PEC)
     Gene Search Search MG1655 PEC by gene name:  guaC
Related strains
     Strains Search Search strains by gene name:  guaC   Search strains by all related name:  guaC b0104 ECK0104 f35 JW0101

General information  (Go to Linear View:)
 Gene Name guaC  
 Alternative name b0104,ECK0104,f35,JW0101  
 Location, Length 113,444 - 114,487 (  +  ) ;   2.45 min ; 1044 (bp) ,   347 (aa) Go to Linear View
 Product GMP reductase  
 Operon Name guaC  
 Note GO_component: GO:0005737 - cytoplasm; GO_process: GO:0009152 - purine ribonucleotide biosynthetic process; GO_process: GO:0015949 - nucleobase, nucleoside and nucleotide interconversion  
 Function enzyme; Purine ribonucleotide biosynthesis  
 Gene Ontology GO:0003824 ; catalytic activity ( guaC )
GO:0003920 ; GMP reductase activity ( guaC )
GO:0005515 ; protein binding ( guaC )
GO:0006163 ; purine nucleotide metabolic process ( guaC )
GO:0008152 ; metabolic process ( guaC )
GO:0009117 ; nucleotide metabolic process ( guaC )
GO:0016491 ; oxidoreductase activity ( guaC )
GO:0030955 ; potassium ion binding ( guaC )
GO:0046872 ; metal ion binding ( guaC )
 PID 1786293  
 EC number
  (KEGG Pathway)   		1.7.1.7  
Verified Protein Starts (data compiled from literature and appropriate citations are available from EcoGene)
     EcoGene guaC ( EG10422 )  
    Number of removed 0 aa cleaved  
SWISS-PROT  ( Show details [ 2 more] )
  botton Entry name(Acc.no) GUAC_ECOLI ( P60560 ; P15344; P78048 )
    -  Protein name GMP reductase  
    -  Synonyms EC 1.7.1.7, Guanosine 5'-monophosphate oxidoreductase, Guanosine monophosphate reductase  
    -  Gene name Name=guaC; OrderedLocusNames=b0104;  

 Linear View (Whole Mode)
View Location
   105.0  –  130.0 (KBP)

Homology Analysis
BLAST
    Bacteria
         GTOP guaC (  homologous genes of other bacterias  )  
    PDB     (database updated : 2007.02.20 )
         PSI-BLAST Chain A, Structure Of Human Guanosine Monophosphate Reductase Gmpr1 In Complex With Gmp  
    SWISS-PROT     (database updated : 2007.02.20 )
         BLAST GMP reductase (Guanosine 5'-monophosphate oxidoreductase) (Guanosine monophosphate reductase)  
         PSI-BLAST GMP reductase
    nr     (database updated : 2007.02.20 )
         BLAST guanosine 5'-monophosphate oxidoreductase [Escherichia coli K12]  
Pfam 28.0   (database updated : 2015-05 )
    Pfam
PROSITE
    PROSITE ASN_GLYCOSYLATION    CAMP_PHOSPHO_SITE    PKC_PHOSPHO_SITE    CK2_PHOSPHO_SITE    MYRISTYL    IMP_DH_GMP_RED     

Other Cross-Reference
    COG COG0516F 
    EcoCyc guaC 

MMBR References
Biochem J. 1988;255(1):35-43.
Nucleotide sequence of the gene encoding the GMP reductase of Escherichia coli K12.
Andrews SC, Guest JR. ( 2904262 )
Gene. 1985;40(1):141-3.
Cloning of the Escherichia coli K-12 guaC gene following its transposition into the RP4::Mu cointegrate.
Moffat KG, Mackinnon G. ( 3005121 )
J Bacteriol. 1988;170(1):463-7.
Genetic and molecular characterization of the guaC-nadC-aroP region of Escherichia coli K-12.
Roberts RE, Lienhard CI, Gaines CG, Smith JM, Guest JR. ( 3275629 )

Sequences
Amino acid
FASTA format 
0001 MRIEEDLKLG FKDVLIRPKR STLKSRSDVE LERQFTFKHS GQSWSGVPII AANMDTVGTF SMASALASFD 
0071 ILTAVHKHYS VEEWQAFINN SSADVLKHVM VSTGTSDADF EKTKQILDLN PALNFVCIDV ANGYSEHFVQ 
0141 FVAKAREAWP TKTICAGNVV TGEMCEELIL SGADIVKVGI GPGSVCTTRV KTGVGYPQLS AVIECADAAH 
0211 GLGGMIVSDG GCTTPGDVAK AFGGGADFVM LGGMLAGHEE SGGRIVEENG EKFMLFYGMS SESAMKRHVG 
0281 GVAEYRAAEG KTVKLPLRGP VENTARDILG GLRSACTYVG ASRLKELTKR TTFIRVQEQE NRIFNNL
Nucleotide
FASTA format

View sequence out neighbor 100bp 
-100                                             AGACAATTTC GCAGTCTTGC GCCGCATTGA 
-070 TTAGTGCGTA TGATAGCGTC ACTGGAGTTG CGCTCTTACC CTTATAGCCA TTAACCCCAG GAATCCGCAC 
0001 atgcgtattg aagaagatct gaagttaggt tttaaagacg ttctcatccg ccctaaacgc tccactctta 
0071 aaagccgttc cgatgttgaa ctggaacgtc aattcacctt caaacattca ggtcagagct ggtccggcgt 
0141 gccgattatc gccgcaaata tggacaccgt aggcacattt tctatggcct ctgcgctggc ttcttttgat 
0211 attttgactg ctgtgcataa acactattct gtcgaagagt ggcaagcgtt tatcaacaat tcttccgctg 
0281 atgtgctgaa acatgtgatg gtttctaccg gtacgtctga tgcggatttc gaaaaaacta aacagattct 
0351 cgacctgaac ccggcattaa acttcgtttg tattgacgtg gcgaatggtt attccgaaca cttcgtgcag 
0421 ttcgttgcga aagcgcgtga agcgtggccg accaaaacca tttgtgctgg taacgtagtg actggtgaaa 
0491 tgtgtgagga gcttatcctc tcaggtgccg atatcgttaa agttggcatt ggcccaggtt ctgtttgtac 
0561 aactcgcgtc aaaacaggcg tcggttatcc gcaactttct gcggtaatcg aatgtgccga tgctgcgcac 
0631 ggtctgggcg gaatgatcgt cagcgatggt ggctgcacca cgccgggcga tgtggcgaaa gcctttggcg 
0701 gcggtgccga tttcgtcatg cttggcggca tgctggcggg ccacgaagag agcggcggtc gcatcgttga 
0771 ggagaacggc gagaaattta tgctgttcta cggcatgagc tccgagtctg cgatgaaacg tcacgttggc 
0841 ggcgttgcgg aatatcgcgc agcagaaggt aaaaccgtta agctgccgct gcgaggcccg gttgaaaata 
0911 ccgcgcgaga tattttgggc ggcctgcgtt cagcttgtac atacgttggg gcttcacgcc tgaaagagct 
0981 gaccaagcgc accacgttta ttcgtgtgca ggaacaagaa aaccgcatct tcaacaacct gtaaTCTCCC 
1051 AACGCTGGCG TGGAGCAACA CGCCAGCGTT ATCCCATCCC ACTCATCGCA TCGCCTAAAT GGAAAATTGG 
1121 CAGATACATT GCCACCACCA GCGT