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PEC Original Annotations
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Essentiality
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Class
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essential
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References (PMID)
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Proc Natl Acad Sci U S A. 1994;91(13):5813-7.
GTP-dependent polymerization of Escherichia coli FtsZ protein to form tubules.
Bramhill D, Thompson CM.
(
8016071
)
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Deletion
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OCR30,31-3 (BK2-1 / AK1-1)
(D)
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Related gene (W3110 PEC)
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Gene Search
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Search MG1655 PEC by gene name:
ftsZ
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Related strains
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Strains Search
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Search strains by gene name:
ftsZ
Search strains by all related name:
ftsZ b0095 ECK0096 JW0093 sfiB sulB
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General information (Go to Linear View: )
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Gene Name
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ftsZ
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Alternative name
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b0095,ECK0096,JW0093,sfiB,sulB
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Location, Length
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105,305 - 106,456
(
+
)
;
2.27
min
;
1152
(bp) ,
383
(aa)
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Product
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GTP-binding tubulin-like cell division protein
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Operon Name
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mraZ-rsmH-ftsLI-murEF-mraY-murD-ftsW-murGC-ddlB-ftsQAZ-lpxC
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Note
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cell division; forms circumferential ring; tubulin-like GTP-binding protein and GTPase; GO_component: GO:0005737 - cytoplasm
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Function
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enzyme; Cell division
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Gene Ontology
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GO:0000166
;
nucleotide binding ( ftsZ )
GO:0000917
;
barrier septum formation ( ftsZ )
GO:0003924
;
GTPase activity ( ftsZ )
GO:0005515
;
protein binding ( ftsZ )
GO:0005525
;
GTP binding ( ftsZ )
GO:0005737
;
cytoplasm ( ftsZ )
GO:0007049
;
cell cycle ( ftsZ )
GO:0043234
;
protein complex ( ftsZ )
GO:0051258
;
protein polymerization ( ftsZ )
GO:0051301
;
cell division ( ftsZ )
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PID
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1786284
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EC number
(KEGG Pathway)
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Verified Protein Starts
(data
compiled from literature and appropriate citations are available from EcoGene)
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EcoGene
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ftsZ
(
EG10347
)
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Number of removed
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0 aa cleaved
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SWISS-PROT
(
Show details
)
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Entry name(Acc.no)
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FTSZ_ECOLI
(
P06138
;
P77857; P78047
)
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- Protein name
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Cell division protein ftsZ.
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- Synonyms
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- Gene name
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OrderedLocusNames=b0095, c0113, z0105, ECs0099;
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Homology Analysis
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BLAST
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Bacteria
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GTOP
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ftsZ
(
homologous genes of other bacterias
)
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PDB
(database updated :
2007.02.20
)
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PSI-BLAST
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Chain A, Ftsz, T7 Mutated, Domain Swapped (T. Maritima)
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SWISS-PROT
(database updated :
2007.02.20
)
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BLAST
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Cell division protein ftsZ
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PSI-BLAST
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Tubulin beta-1 chain
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nr
(database updated :
2007.02.20
)
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BLAST
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cell division protein FtsZ [Escherichia coli O157:H7 EDL933]
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Pfam 28.0
(database updated :
2015-05
)
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Pfam
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PROSITE
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PROSITE
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ASN_GLYCOSYLATION
PKC_PHOSPHO_SITE
CK2_PHOSPHO_SITE
MYRISTYL
AMIDATION
FTSZ_1
FTSZ_2
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MMBR References
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J Bacteriol. 1987;169(5):1938-42.
Regulation of cell division in Escherichia coli K-12: probable interactions among proteins FtsQ, FtsA, and FtsZ.
Descoteaux A, Drapeau GR.
(
3032902
)
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EMBO J. 1993;12:3957-3965
Transcription of ftsZ oscillates during the cell cycle of Escherichia coli.
Garrido, T., M. Sanchez, P. Palacios, M. Aldea, and M. Vicente.
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J Bacteriol. 1996;178:7167-7172
FtsA is localized to the septum in an FtsZ-dependent manner.
Addinall, S. G., and J. Lutkenhaus.
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J Bacteriol. 1986;165(1):66-71.
SOS-independent coupling between DNA replication and cell division in Escherichia coli.
Jaffe A, D'Ari R, Norris V.
(
3001034
)
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EMBO J. 1984;3:1181-1186
Inactivation of essential division genes ftsA, ftsZ, suppresses mutations at sfiB, a locus mediating division inhibition during the SOS response in E. coli.
Jones, C. A., and I. B. Holland.
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J Bacteriol. 1989;171(11):6379-82.
Inhibition of growth of ftsQ, ftsA, and ftsZ mutant cells of Escherichia coli by amplification of a chromosomal region encompassing closely aligned cell division and cell growth genes.
Jung HK, Ishino F, Matsuhashi M.
(
2553679
)
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Trends Genet. 1990;154:1339-1346.
Regulation of cell division in E. coli.
Lutkenhaus, J.
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J Bacteriol. 1983;154(3):1339-46.
Coupling of DNA replication and cell division: sulB is an allele of ftsZ.
Lutkenhaus JF.
(
6343351
)
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Proc Natl Acad Sci U S A. 1996;93:12998-13003
Colocalization of cell division proteins FtsZ and FtsA to cytoskeletal structures in living Escherichia coli cells by using green fluorescent protein.
Ma, X., D. W. Ehrhardt, and W. Margolin.
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J Bacteriol. 1985;163(2):615-22.
Cell shape and division in Escherichia coli: experiments with shape and division mutants.
Begg KJ, Donachie WD.
(
3894330
)
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J Bacteriol. 1990;172(5):2765-8.
FtsZ regulates frequency of cell division in Escherichia coli.
Bi E, Lutkenhaus J.
(
2158979
)
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J Bacteriol. 1992;174:5414-5423
Isolation and characterization of ftsZ alleles that affect septal morphology.
Bi, E., and J. Lutkenhaus.
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Mol Microbiol. 1991;5(7):1681-6.
Preferential cytoplasmic location of FtsZ, a protein essential for Escherichia coli septation.
Pla J, Sanchez M, Palacios P, Vicente M, Aldea M.
(
1943703
)
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J Bacteriol. 1998;180:1053-1062
Control of ftsZ expression, cell division, and glutamine metabolism in Luria-Bertani medium by the alarmone ppGpp in Escherichia coli.
Powell, B. S., and D. L. Court.
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Cell. 1997;91(5):685-94.
The MinE ring: an FtsZ-independent cell structure required for selection of the correct division site in E. coli.
Raskin DM, de Boer PA.
(
9393861
)
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Nature. 1992;359(6392):251-4.
Escherichia coli cell-division gene ftsZ encodes a novel GTP-binding protein.
RayChaudhuri D, Park JT.
(
1528267
)
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J Bacteriol. 1984;158(3):1198-201.
Overlapping functional units in a cell division gene cluster in Escherichia coli.
Sullivan NF, Donachie WD.
(
6327635
)
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Bioessays. 1995;17(6):527-36.
Overview of controls in the Escherichia coli cell cycle.
Vinella D, D'Ari R.
(
7575494
)
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Gene. 1985;36(3):241-7.
The nucleotide sequence of the essential cell-division gene ftsZ of Escherichia coli.
Yi QM, Lutkenhaus J.
(
3000876
)
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J Mol Biol. 1985;184(3):399-412.
Structure and expression of the cell division genes ftsQ, ftsA and ftsZ.
Yi QM, Rockenbach S, Ward JE Jr, Lutkenhaus J.
(
2995680
)
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EMBO J. 1990;9:3787-3794
Division genes in Escherichia coli are expressed coordinately to cell septum requirements by gearbox promoters.
Aldea, M., T. Garrido, J. Pla, and M. Vicente.
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Nucleic Acids Res. 1996;24:3065-3070
RNase E processing of essential cell division genes mRNA in Escherichia coli.
Cam, K., G. Rome, H. M. Krisch, and J. P. Bouche.
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J Bacteriol. 1994;176:130-136
Mutations in ftsZ that confer resistance to SulA affect the interaction of FtsZ with GTP.
Dai, K., A. Mukherjee, Y. Xu, and J. Lutkenhaus.
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J Bacteriol. 1991;173(11):3500-6.
ftsZ is an essential cell division gene in Escherichia coli.
Dai K, Lutkenhaus J.
(
2045370
)
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| Sequences |
Amino acid
FASTA format
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0001 MFEPMELTND AVIKVIGVGG GGGNAVEHMV RERIEGVEFF AVNTDAQALR KTAVGQTIQI GSGITKGLGA
0071 GANPEVGRNA ADEDRDALRA ALEGADMVFI AAGMGGGTGT GAAPVVAEVA KDLGILTVAV VTKPFNFEGK
0141 KRMAFAEQGI TELSKHVDSL ITIPNDKLLK VLGRGISLLD AFGAANDVLK GAVQGIAELI TRPGLMNVDF
0211 ADVRTVMSEM GYAMMGSGVA SGEDRAEEAA EMAISSPLLE DIDLSGARGV LVNITAGFDL RLDEFETVGN
0281 TIRAFASDNA TVVIGTSLDP DMNDELRVTV VATGIGMDKR PEITLVTNKQ VQQPVMDRYQ QHGMAPLTQE
0351 QKPVAKVVND NAPQTAKEPD YLDIPAFLRK QAD
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Nucleotide
FASTA format
View sequence out neighbor 100bp
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-100 GATCAAGCGA CTCAATAGTT GGCTGCGAAA
-070 AGAGTTTTAA TTTTTATGAG GCCGACGATG ATTACGGCCT CAGGCGACAG GCACAAATCG GAGAGAAACT
0001 atgtttgaac caatggaact taccaatgac gcggtgatta aagtcatcgg cgtcggcggc ggcggcggta
0071 atgctgttga acacatggtg cgcgagcgca ttgaaggtgt tgaattcttc gcggtaaata ccgatgcaca
0141 agcgctgcgt aaaacagcgg ttggacagac gattcaaatc ggtagcggta tcaccaaagg actgggcgct
0211 ggcgctaatc cagaagttgg ccgcaatgcg gctgatgagg atcgcgatgc attgcgtgcg gcgctggaag
0281 gtgcagacat ggtctttatt gctgcgggta tgggtggtgg taccggtaca ggtgcagcac cagtcgtcgc
0351 tgaagtggca aaagatttgg gtatcctgac cgttgctgtc gtcactaagc ctttcaactt tgaaggcaag
0421 aagcgtatgg cattcgcgga gcaggggatc actgaactgt ccaagcatgt ggactctctg atcactatcc
0491 cgaacgacaa actgctgaaa gttctgggcc gcggtatctc cctgctggat gcgtttggcg cagcgaacga
0561 tgtactgaaa ggcgctgtgc aaggtatcgc tgaactgatt actcgtccgg gtttgatgaa cgtggacttt
0631 gcagacgtac gcaccgtaat gtctgagatg ggctacgcaa tgatgggttc tggcgtggcg agcggtgaag
0701 accgtgcgga agaagctgct gaaatggcta tctcttctcc gctgctggaa gatatcgacc tgtctggcgc
0771 gcgcggcgtg ctggttaaca tcacggcggg cttcgacctg cgtctggatg agttcgaaac ggtaggtaac
0841 accatccgtg catttgcttc cgacaacgcg actgtggtta tcggtacttc tcttgacccg gatatgaatg
0911 acgagctgcg cgtaaccgtt gttgcgacag gtatcggcat ggacaaacgt cctgaaatca ctctggtgac
0981 caataagcag gttcagcagc cagtgatgga tcgctaccag cagcatggga tggctccgct gacccaggag
1051 cagaagccgg ttgctaaagt cgtgaatgac aatgcgccgc aaactgcgaa agagccggat tatctggata
1121 tcccagcatt cctgcgtaag caagctgatt aaGAATTGAC TGGAATTTGG GTTTCGAGGC TCTTTGTGCT
1191 AAACTGGCCC GCCGAATGTA TAGTACACTT CGGTTGGATA GGTAATTTGG CGAGATAATA CG
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