PEC Original Annotations
|
Essentiality
|
Class
|
essential
|
References (PMID)
|
Proc Natl Acad Sci U S A. 1978;75(2):664-8.
On the process of cellular division in Escherichia coli: a series of mutants of E. coli altered in the penicillin-binding proteins.
Suzuki H, Nishimura Y, Hirota Y.
(
345275
)
|
|
Deletion
|
OCR30,31-3 (BK2-1 / AK1-1)
(D)
|
Related gene (W3110 PEC)
|
Gene Search
|
Search MG1655 PEC by gene name:
ftsI
|
Related strains
|
Strains Search
|
Search strains by gene name:
ftsI
Search strains by all related name:
ftsI b0084 ECK0085 JW0082 pbpB sep
|
General information (Go to Linear View:)
|
Gene Name
|
ftsI
|
Alternative name
|
b0084,ECK0085,JW0082,pbpB,sep
|
Location, Length
|
91,413 - 93,179
(
+
)
;
1.97
min
;
1767
(bp) ,
588
(aa)
|
Product
|
transpeptidase involved in septal peptidoglycan synthesis (penicillin-binding protein 3)
|
Operon Name
|
mraZ-rsmH-ftsLI-murEF-mraY-murD-ftsW-murGC-ddlB-ftsQAZ-lpxC
|
Note
|
septum formation; penicillin-binding protein 3; peptidoglycan synthetase; GO_component: GO:0009274 - peptidoglycan-based cell wall; GO_component: GO:0019866 - organelle inner membrane; GO_process: GO:0009252 - peptidoglycan biosynthetic process; GO_process: GO:0042493 - response to drug
|
Function
|
enzyme; Cell division
|
Gene Ontology
|
GO:0003824
;
catalytic activity ( ftsI )
GO:0005886
;
plasma membrane ( ftsI )
GO:0007047
;
cell wall organization and biogenesis ( ftsI )
GO:0007049
;
cell cycle ( ftsI )
GO:0008360
;
regulation of cell shape ( ftsI )
GO:0008658
;
penicillin binding ( ftsI )
GO:0008955
;
peptidoglycan glycosyltransferase activity ( ftsI )
GO:0009252
;
peptidoglycan biosynthetic process ( ftsI )
GO:0009273
;
peptidoglycan-based cell wall biogenesis ( ftsI )
GO:0016020
;
membrane ( ftsI )
GO:0016021
;
integral to membrane ( ftsI )
GO:0016740
;
transferase activity ( ftsI )
GO:0016757
;
transferase activity, transferring glycosyl groups ( ftsI )
GO:0046677
;
response to antibiotic ( ftsI )
GO:0051301
;
cell division ( ftsI )
|
PID
|
1786272
|
EC number
(KEGG Pathway)
|
|
SWISS-PROT
(
Show details
[
1
more]
)
|
Entry name(Acc.no)
|
FTSI_ECOLI
(
P04286
)
|
- Protein name
|
Peptidoglycan synthetase ftsI precursor
|
- Synonyms
|
EC 2.4.1.129, Peptidoglycan glycosyltransferase 3, Penicillin-binding protein 3, PBP-3
|
- Gene name
|
Name=ftsI; Synonyms=pbpB; OrderedLocusNames=b0084, z0094, ECs0088;
|
MMBR References
|
J Bacteriol. 1996;178:5402-5409
The non-penicillin-binding module of the tripartite penicillin-binding protein 3 of Escherichia coli is required for folding and/or stability of the penicillin-binding module and the membrane-anchoring module confers cell septation activity on the folded structure.
Goffin, C., C. Fraipont, J. Ayala, M. Terrak, M. Nguyen-Disteche, and J. M. Ghuysen.
|
J Bacteriol. 1997;179:5802-5811
A promoter for the first nine genes of the Escherichia coli mra cluster of cell division and cell envelope biosynthesis genes, including ftsI and ftsW.
Hara, H., S. Yasuda, K. Horiuchi, and J. T. Park.
|
J Bacteriol. 1989;171(11):6379-82.
Inhibition of growth of ftsQ, ftsA, and ftsZ mutant cells of Escherichia coli by amplification of a chromosomal region encompassing closely aligned cell division and cell growth genes.
Jung HK, Ishino F, Matsuhashi M.
(
2553679
)
|
J Bacteriol. 1985;163(2):615-22.
Cell shape and division in Escherichia coli: experiments with shape and division mutants.
Begg KJ, Donachie WD.
(
3894330
)
|
J Bacteriol. 1989;171(11):6126-34.
Organization of the murE-murG region of Escherichia coli: identification of the murD gene encoding the D-glutamic-acid-adding enzyme.
Mengin-Lecreulx D, Parquet C, Desviat LR, Pla J, Flouret B, Ayala JA, van Heijenoort J.
(
2681153
)
|
Mol Gen Genet. 1983;191(1):1-9.
On the process of cellular division in Escherichia coli: nucleotide sequence of the gene for penicillin-binding protein 3.
Nakamura M, Maruyama IN, Soma M, Kato J, Suzuki H, Horota Y.
(
6350821
)
|
Sequences |
Amino acid
FASTA format
|
0001 MKAAAKTQKP KRQEEHANFI SWRFALLCGC ILLALAFLLG RVAWLQVISP DMLVKEGDMR SLRVQQVSTS
0071 RGMITDRSGR PLAVSVPVKA IWADPKEVHD AGGISVGDRW KALANALNIP LDQLSARINA NPKGRFIYLA
0141 RQVNPDMADY IKKLKLPGIH LREESRRYYP SGEVTAHLIG FTNVDSQGIE GVEKSFDKWL TGQPGERIVR
0211 KDRYGRVIED ISSTDSQAAH NLALSIDERL QALVYRELNN AVAFNKAESG SAVLVDVNTG EVLAMANSPS
0281 YNPNNLSGTP KEAMRNRTIT DVFEPGSTVK PMVVMTALQR GVVRENSVLN TIPYRINGHE IKDVARYSEL
0351 TLTGVLQKSS NVGVSKLALA MPSSALVDTY SRFGLGKATN LGLVGERSGL YPQKQRWSDI ERATFSFGYG
0421 LMVTPLQLAR VYATIGSYGI YRPLSITKVD PPVPGERVFP ESIVRTVVHM MESVALPGGG GVKAAIKGYR
0491 IAIKTGTAKK VGPDGRYINK YIAYTAGVAP ASQPRFALVV VINDPQAGKY YGGAVSAPVF GAIMGGVLRT
0561 MNIEPDALTT GDKNEFVINQ GEGTGGRS
|
Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 TAGCCGGGTG GAAAGGATCG CCACGGAAAA
-070 GCTGCAAATG CAGCATGTTG ATCCGTCACA AGAAAATATC GTAGTGCAAA AATAAGGATA AACGCGACGC
0001 atgaaagcag cggcgaaaac gcagaaacca aaacgtcagg aagaacatgc caactttatc agttggcgtt
0071 ttgcgttgtt atgcggctgt attctcctgg cgctggcttt tctgctcgga cgcgtagcgt ggttacaagt
0141 tatctccccg gatatgctgg tgaaagaggg cgacatgcgt tctcttcgcg ttcagcaagt ttccacctcc
0211 cgcggcatga ttactgaccg ttctggtcgc ccgttagcgg tgagcgtgcc ggtaaaagcg atttgggctg
0281 acccgaaaga agtgcatgac gctggcggta tcagcgtcgg tgaccgctgg aaggcgctgg ctaacgcgct
0351 caatattccg ctggatcagc tttcagcccg cattaacgcc aacccgaaag ggcgctttat ttatctggcg
0421 cgtcaggtga accctgacat ggcggactac atcaaaaaac tgaaactgcc ggggattcat ctgcgtgaag
0491 agtctcgccg ttactatccg tccggcgaag tgactgctca cctcatcggc tttactaacg tcgatagtca
0561 agggattgag ggcgttgaga agagtttcga taaatggctt accgggcagc cgggtgagcg cattgtgcgt
0631 aaagaccgct atggtcgcgt aattgaagat atttcttcta ctgacagcca ggcagcgcac aacctggcgc
0701 tgagtattga tgaacgcctg caggcgctgg tttatcgcga actgaacaac gcggtggcct ttaacaaggc
0771 tgaatctggt agcgccgtgc tggtggatgt caacaccggt gaagtgctgg cgatggctaa cagcccgtca
0841 tacaacccta acaatctgag cggcacgccg aaagaggcga tgcgtaaccg taccatcacc gacgtgtttg
0911 aaccgggctc aacggttaaa ccgatggtgg taatgaccgc gttgcaacgt ggcgtggtgc gggaaaactc
0981 ggtactcaat accattcctt atcgaattaa cggccacgaa atcaaagacg tggcacgcta cagcgaatta
1051 accctgaccg gggtattaca gaagtcgagt aacgtcggtg tttccaagct ggcgttagcg atgccgtcct
1121 cagcgttagt agatacttac tcacgttttg gactgggaaa agcgaccaat ttggggttgg tcggagaacg
1191 cagtggctta tatcctcaaa aacaacggtg gtctgacata gagagggcca ccttctcttt cggctacggg
1261 ctaatggtaa caccattaca gttagcgcga gtctacgcaa ctatcggcag ctacggcatt tatcgcccac
1331 tgtcgattac caaagttgac cccccggttc ccggtgaacg tgtcttcccg gaatccattg tccgcactgt
1401 ggtgcatatg atggaaagcg tggcgctacc aggcggcggc ggcgtgaagg cggcgattaa aggctatcgt
1471 atcgccatta aaaccggtac cgcgaaaaag gtcgggccgg acggtcgcta catcaataaa tatattgctt
1541 ataccgcagg cgttgcgcct gcgagtcagc cgcgcttcgc gctggttgtt gttatcaacg atccgcaggc
1611 gggtaaatac tacggcggcg ccgtttccgc gccggtcttt ggtgccatca tgggcggcgt attgcgtacc
1681 atgaacatcg agccggatgc gctgacaacg ggcgataaaa atgaatttgt gattaatcaa ggcgagggga
1751 caggtggcag atcgtaaTTT GCGCGACCTT CTTGCTCCGT GGGTGCCAGA CGCACCTTCG CGAGCACTGC
1821 GAGAGATGAC ACTCGACAGC CGTGTGGCTG CGGCGGGCGA TCTCTTT
|